Graphene-kaolin composite sponge for rapid and riskless hemostasis

Colloids and Surfaces. B, Biointerfaces
Yuping LiangXing Wang

Abstract

Kaolin is an effective and safe hemostatic agent for hemostasis. However, its ontic powder is difficult to use in actual practice. To develop a wieldy and powerful hemostat, composite strategy is usually a good choice. Herein, we developed a graphene-kaolin composite sponge (GKCS), synthesized with graphene oxide sheets, linker molecules and kaolin powders through a facile hydrothermal reaction. SEM observations support that GKCS has a porous structure, and EDS mapping further confirms that kaolin powders are embedded in graphene sheets. Once GKCS is exposed to bleeding, plasma is quickly absorbed inside the sponge, meanwhile blood cells are gathered at the interface. The gathered blood cells are in favor of accelerating clotting due to multi stimulations, including concentration, surface charge and activation of hemostatic factors, originating from both kaolin powders and graphene sponge. As a result, GKCS could stop bleeding in approximately 73 s in rabbit artery injury test. Besides, cytotoxicity and hemolysis assessments highlight that GKCS has a good biocompatibility. These remarkable properties suggest that GKCS is a potential riskless hemostatic agent for trauma treatment.

Citations

Sep 5, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Changjiao GanGuifang Dou
Jun 5, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Caiyun ZhengTingli Lu
Aug 7, 2019·Environmental Science and Pollution Research International·Yakun ZhangXinyu Jiang
Nov 8, 2019·Advanced Healthcare Materials·Xiao-Xiong WangYun-Ze Long
Oct 24, 2018·Journal of Functional Biomaterials·Marina MassaroSerena Riela
Mar 13, 2021·International Journal of Biological Macromolecules·Caiyun ZhengTingli Lu
Jul 4, 2021·Colloids and Surfaces. B, Biointerfaces·Jessica Borges-VilchesKatherina Fernández
Apr 17, 2020·ACS Applied Materials & Interfaces·Zhengguo WuXiaoying Wang
Jun 28, 2019·ACS Applied Materials & Interfaces·Yuping LiangXing Wang
Oct 13, 2021·Nature Communications·Yan CuiYi Zhang

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