Graphene oxide-modified ZnO particles: synthesis, characterization, and antibacterial properties

International Journal of Nanomedicine
Linlin Zhong, Kyusik Yun

Abstract

Nanosized ZnO particles with diameters of 15 nm were prepared with a solution precipitation method at low cost and high yield. The synthesis of the particles was functionalized by the organic solvent dimethylformamide, and the particles were covalently bonded to the surface of graphene oxide. The morphology of the graphene oxide sheets and ZnO particles was confirmed with field emission scanning electron microscopy and biological atomic force microscopy. Fourier transform infrared spectroscopy and X-ray diffraction were used to analyze the physical and chemical properties of the ZnO/graphene oxide composites that differed from those of the individual components. Enhanced electrochemical properties were detected with cyclic voltammetry, with a redox peak of the composites at 0.025 mV. Excellent antibacterial activity of ZnO/graphene oxide composites was observed with a microdilution method in which minimum inhibitory concentrations of 6.25 µg/mL for Escherichia coli and Salmonella typhimurium, 12.5 µg/mL for Bacillus subtilis, and 25 µg/mL for Enterococcus faecalis. After further study of the antibacterial mechanism, we concluded that a vast number of reactive oxygen species formed on the surface of composites, improving antibac...Continue Reading

Citations

Mar 8, 2016·ACS Applied Materials & Interfaces·Md Azahar AliBansi Dhar Malhotra
Mar 8, 2013·Biomaterials·Chao LiDaxiang Cui
Oct 9, 2019·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Yasmin Abo-Zeid, Gareth R Williams
May 24, 2020·International Journal of Molecular Sciences·Ana María Díez-Pascual
Dec 4, 2020·International Journal of Molecular Sciences·Yuchao LiSie Chin Tjong
Mar 17, 2021·Water Science and Technology : a Journal of the International Association on Water Pollution Research·B L DineshaM V Ravi
Sep 12, 2017·ACS Applied Materials & Interfaces·Nawab SinghRenu John
Oct 21, 2018·Langmuir : the ACS Journal of Surfaces and Colloids·Diana VisinescuOana Carp

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Methods Mentioned

BETA
biosensors
chip
fluorescence
fluorescence-activated cell sorting
enzyme-linked immunosorbent assay
X-ray
Bio-AFM
FACS

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