Graphene oxide nanoparticles induce hepatic dysfunction through the regulation of innate immune signaling in zebrafish (Danio rerio )

Nanotoxicology
Guanghua XiongHuiqiang Lu

Abstract

Graphene oxide (GO) is an increasingly important nanomaterial that exhibits great promise in the area of bionanotechnology and nanobiomedicine. However, the toxic effects of GO on the vertebrate developmental system are still poorly understood. Here, we aimed to investigate the toxic effects and molecular mechanisms of GO exposure in larval and adult zebrafish. The results showed that the major hepatotoxic phenotype induced by GO in zebrafish embryos was a significant decrease in liver area and a dose-dependent decrease in the hepatocytes. Moreover, the number of macrophages and neutrophils in zebrafish embryos were reduced but the expressions of pro-inflammatory cytokines were increased after GO treatment. High through-put RNA-Seq identified 314 differentially expressed genes (DEGs) in GO-induced zebrafish embryos including 192 up-regulated and 122 down-regulated. KEGG and GO functional analysis revealed that steroid hormone biosynthesis, lipoprotein metabolic process, and PPAR signaling pathway were significantly enriched. Most of the lipid metabolism genes were down-regulated while majority of the immune genes were up-regulated after GO treatment. Moreover, GO induced NF-κB p65 into the nucleus and increased the protein leve...Continue Reading

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Citations

Aug 14, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Nemi MalhotraChung-Der Hsiao
Sep 26, 2020·Frontiers in Pharmacology·Zhiwen YangGuimiao Lin
Feb 11, 2021·Nanomaterials·Pietro BelletFrancesco Filippini
Sep 23, 2021·Journal of Applied Toxicology : JAT·Leila Ghiasvand MohammadkhaniAli Ramazani

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