Graphene oxide nanosheets and d-α-Tocopheryl polyethylene glycol 1000 succinate (TPGS) doping improves biocompatibility and ultrafiltration in polyethersulfone hollow fiber membranes

Journal of Colloid and Interface Science
Akshay ModiJayesh R Bellare

Abstract

Novel graphene oxide (G)-and d-α-Tocopheryl polyethylene glycol 1000 succinate (T)-doped polyethersulfone (P) hollow fiber membranes (GTP HFMs) were efficiently prepared. GTP HFMs were found to be a desirable biocompatible substrate for attachment and proliferation of human embryonic kidney-293 (HEK-293) cells. Significantly high porosity (94.58±1.1%), low contact angle (61.1±2.5°), low hemolysis (0.58% in batch mode and 0.64% in continuous mode), low terminal complement complex activation (SC5b-9 marker level ∼6.73ng/mL), prolonged blood coagulation time, and low platelet adhesion were measured for GTP HFMs indicating the superior suitability of GTP HFMs for blood-contact applications. Further, SEM and confocal laser microscopy studies showed the significantly high HEK-293 cells attachment and proliferation on GTP HFMs which was corroborated by results of glucose consumption analysis and MTT cell proliferation assay. High ultrafiltration coefficient (110±3mL/m2/h/mmHg), and albumin solute rejection (94.87±0.5%) were also measured for GTP HFMs. Thus, these results clearly indicated that the synergistic effect of additives improved the biocompatibility and ultrafiltration in GTP HFMs. The developed GTP HFMs can potentially be us...Continue Reading

Citations

Sep 22, 2018·Toxicological Sciences : an Official Journal of the Society of Toxicology·Jian LiBin Liu
Dec 2, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Wei LiuJie Peng
Mar 4, 2021·Environmental Science and Pollution Research International·Bangeppagari ManjunathaSang Joon Lee
Aug 14, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Zhongnan WangJianbin Luo

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