Graphene: The Missing Piece for Cancer Diagnosis?

Sensors
Sandra M A CruzPaula A A P Marques

Abstract

This paper reviews recent advances in graphene-based biosensors development in order to obtain smaller and more portable devices with better performance for earlier cancer detection. In fact, the potential of Graphene for sensitive detection and chemical/biological free-label applications results from its exceptional physicochemical properties such as high electrical and thermal conductivity, aspect-ratio, optical transparency and remarkable mechanical and chemical stability. Herein we start by providing a general overview of the types of graphene and its derivatives, briefly describing the synthesis procedure and main properties. It follows the reference to different routes to engineer the graphene surface for sensing applications with organic biomolecules and nanoparticles for the development of advanced biosensing platforms able to detect/quantify the characteristic cancer biomolecules in biological fluids or overexpressed on cancerous cells surface with elevated sensitivity, selectivity and stability. We then describe the application of graphene in optical imaging methods such as photoluminescence and Raman imaging, electrochemical sensors for enzymatic biosensing, DNA sensing, and immunosensing. The bioquantification of ca...Continue Reading

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Citations

May 10, 2017·Materials Science & Engineering. C, Materials for Biological Applications·Mojgan SheikhpourAlibakhsh Kasaeian
Sep 12, 2017·Journal of Biomedical Materials Research. Part a·Tahereh ForoutanHadi Zare Zardini
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Dec 14, 2019·Bioscience Reports·Mahdi Rahaie, Saman Khayat Noroozi
Aug 15, 2017·Cellular and Molecular Bioengineering·Zhenjiang Zhang, Michael R King

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Methods Mentioned

BETA
biopsies
surgical resection
biosensors
biosensores
biosensor
biosensing
dissection
surface-enhanced Raman scattering
fluorescence
Raman scattering

Software Mentioned

rGO

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