Graphic analysis of flow-volume curves: a pilot study

BMC Pulmonary Medicine
Jungsil LeeKOLD Study Group

Abstract

Conventional spirometric parameters have shown poor correlation with symptoms and health status of chronic obstructive pulmonary disease (COPD). While it is well-known that the pattern of the expiratory flow-volume curve (EFVC) represents ventilatory dysfunction, little attempts have been made to derive quantitative parameters by analyzing the curve. In this study, we aimed to derive useful parameters from EFVC via graphic analysis and tried to validate them in patients with COPD. Using Graphical Analysis 3.4 Vernier Software, we derived from the EFVC such parameters as area of obstruction (Ao), area of triangle (AT), area of rectangle (AR) and ratio of volume at 75 and 25% peak expiratory flow (PEF) (0.25/0.75 V). For validation, we reviewed clinical and spirometric data of 61 COPD patients from Seoul National University Airway Registry (SNUAR) and Korean obstructive Lung Disease (KOLD) cohorts. Of all parameters, only RV/TLC significantly correlated with scores from St. George's Respiratory Questionnaire (SGRQ) (r = 0.447, p = 0.037). Six-minute walking distance (6MWD) highly correlated with Ao/AR (r = -0.618, p = 0.005) and Ao/PEF (r = -0.581, p = 0.009) whereas neither FEV1 nor FEV1/FVC had significant correlation with 6MWD...Continue Reading

References

Jan 1, 1979·Respiration; International Review of Thoracic Diseases·J C VermaakM A de Kock
Oct 1, 1988·Chest·M C KappT J Witek
Jan 25, 2005·American Journal of Respiratory and Critical Care Medicine·Fabio PittaRik Gosselink
Feb 21, 2009·COPD·Paul W Jones
Feb 24, 2011·Respirology : Official Journal of the Asian Pacific Society of Respirology·Kwang H YooSung K Han
Jul 25, 2013·Journal of Clinical Monitoring and Computing·E M WilliamsR Colasanti
May 23, 2014·Tuberculosis and Respiratory Diseases·Tai Sun ParkUNKNOWN KOLD Study Group
Nov 2, 2014·The European Respiratory Journal·Henrik WatzMartijn A Spruit

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Citations

Aug 10, 2016·BMC Pulmonary Medicine·Jungsil LeeUNKNOWN KOLD Study Group
Sep 1, 2017·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Andreas VoskrebenzevJens Vogel-Claussen
Dec 6, 2019·BMJ Open Respiratory Research·Octavian C Ioachimescu, James K Stoller
May 9, 2021·NPJ Primary Care Respiratory Medicine·Sotirios KakavasIoannis Pantazopoulos
Jun 12, 2021·PloS One·Jyotika ErramDaniel T Cannon

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Software Mentioned

Vernier
PASW Statistics
SPSS
Graphical Analysis

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