GRASPs in Golgi Structure and Function

Frontiers in Cell and Developmental Biology
Xiaoyan Zhang, Yanzhuang Wang

Abstract

The Golgi apparatus is a central intracellular membrane organelle for trafficking and modification of proteins and lipids. Its basic structure is a stack of tightly aligned flat cisternae. In mammalian cells, dozens of stacks are concentrated in the pericentriolar region and laterally connected to form a ribbon. Despite extensive research in the last decades, how this unique structure is formed and why its formation is important for proper Golgi functioning remain largely unknown. The Golgi ReAssembly Stacking Proteins, GRASP65, and GRASP55, are so far the only proteins shown to function in Golgi stacking. They are peripheral membrane proteins on the cytoplasmic face of the Golgi cisternae that form trans-oligomers through their N-terminal GRASP domain, and thereby function as the "glue" to stick adjacent cisternae together into a stack and to link Golgi stacks into a ribbon. Depletion of GRASPs in cells disrupts the Golgi structure and results in accelerated protein trafficking and defective glycosylation. In this minireview we summarize our current knowledge on how GRASPs function in Golgi structure formation and discuss why Golgi structure formation is important for its function.

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Mar 15, 2018·Journal of Cell Science·Emily K HermanAnastasios D Tsaousis
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Oct 6, 2020·Frontiers in Cell and Developmental Biology·Qiang HeWei Lu
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May 4, 2017·Proceedings of the National Academy of Sciences of the United States of America·Masashi Tachikawa, Atsushi Mochizuki
Aug 10, 2019·Frontiers in Cell and Developmental Biology·Fabiola MascanzoniAntonino Colanzi
Oct 13, 2019·Journal of Cell Science·Xiaoyan ZhangYanzhuang Wang
Oct 6, 2020·Frontiers in Cell and Developmental Biology·Shuwen DengWei Lu
Nov 22, 2019·Current Opinion in Cell Biology·Yamini RavichandranJean-Baptiste Manneville
May 1, 2021·International Journal of Molecular Sciences·Alazne Arrazola SastreJosé L Zugaza

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Datasets Mentioned

BETA
GM130

Methods Mentioned

BETA
glycosylation
glycosylations
flow cytometry

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