Grass pollen sublingual immunotherapy tablets provide long-term relief of grass pollen-associated allergic rhinitis and reduce the risk of asthma: findings from a retrospective, real-world database subanalysis

Expert Review of Clinical Immunology
Philippe DevillierJ Heinrich

Abstract

We assessed real-world, long-term effectiveness of two marketed sublingual immunotherapy (SLIT) tablets for allergic rhinitis (AR), and their impact on allergic asthma (AA) onset/progression. Retrospective, longitudinal German prescription database subanalysis of AR patients receiving 5- or 1-grass pollen SLIT tablets (n = 1,466/1,385), versus patients not using allergy immunotherapy (AIT) (n = 71,275). Primary endpoint: change over time in AR symptomatic medication prescriptions after treatment cessation; secondary endpoints: new asthma onset, and change over time in asthma medication prescriptions during treatment/follow-up periods. Mean number of AR medication prescriptions was significantly decreased during follow-up (of up to 6 years) with both SLIT tablets versus the non-AIT group (p < 0.001). Over the full-analysis period, proportions of patients with new-onset asthma were 8.8% (odds ratio: 0.676, p = 0.011), 10.3% (odds ratio: 0.720, p = 0.060) and 11.6% in the 5- and 1-grass pollen SLIT tablet and non-AIT groups, respectively. For all treatment-analysis periods, both SLIT tablet groups were associated with fewer asthma medication prescriptions versus non-AIT controls. These findings confirm the real-world benefits of 5...Continue Reading

References

Oct 14, 2004·The Journal of Allergy and Clinical Immunology·Elio NovembreAlberto Vierucci
Feb 12, 2005·Current Medical Research and Opinion·Michael S Blaiss, UNKNOWN Allergic Rhinitis in Schoolchildren Consensus Group
Aug 30, 2008·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Maurizio MarognaSalvatore Tripodi
Nov 10, 2009·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·H ChabreP Moingeon
Nov 10, 2011·International Journal of Immunopathology and Pharmacology·G L MarsegliaM La Rosa
Dec 20, 2011·Therapeutic Advances in Respiratory Disease·Tunis Ozdoganoglu, Murat Songu
Jul 20, 2012·Allergy and Asthma Proceedings·Ashraf Uzzaman, Rachel Story
May 15, 2013·The World Allergy Organization Journal·Daniel C WilliamsPeter K Smith
Aug 21, 2013·Paediatric Drugs·Olympia A TsilochristouNikolaos G Papadopoulos
Apr 1, 2014·The World Allergy Organization Journal·Giorgio Walter CanonicaOsman Yusuf
Apr 9, 2014·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·L D ArchilaW W Kwok
Jun 23, 2015·International Journal of Applied & Basic Medical Research·Rajiv Mahajan
Jul 15, 2015·The Journal of Allergy and Clinical Immunology·Marek JutelCezmi A Akdis
Sep 12, 2015·Expert Review of Clinical Immunology·Giorgio CiprandiAmelia Licari
Sep 16, 2015·The Journal of Allergy and Clinical Immunology·Jochen SchmittEike Gunther Wüstenberg
Nov 26, 2015·Drug Design, Development and Therapy·Alessandra ScaparrottaFrancesco Chiarelli
Oct 30, 2016·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·P DevillierO de Beaumont
Sep 23, 2016·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Maria KristiansenAziz Sheikh
Dec 14, 2016·The New England Journal of Medicine·Rachel E ShermanRobert M Califf
Jul 12, 2017·The Journal of Allergy and Clinical Immunology·Erkka ValovirtaUNKNOWN GAP investigators
Aug 3, 2017·The New England Journal of Medicine·Thomas R Frieden
Sep 14, 2017·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Susanne HalkenAntonella Muraro

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Citations

Jul 11, 2018·Clinical Otolaryngology : Official Journal of ENT-UK ; Official Journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·Wytske J FokkensPeter W Hellings
Nov 7, 2019·Current Opinion in Pulmonary Medicine·Silvia Sánchez-GarcíaJavier Domínguez-Ortega
Mar 7, 2020·Expert Review of Respiratory Medicine·Philippe DevillierMathieu Molimard
Sep 24, 2020·Pharmacoepidemiology and Drug Safety·Katja Biering Leth-MøllerAllan Linneberg
May 19, 2020·The Journal of Allergy and Clinical Immunology. in Practice·Moisés A CalderonHendrik Nolte

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