Graves' disease in children in the two decades following implementation of an iodine prophylaxis programme

Central-European Journal of Immunology
Ada BorowiecAnna M Kucharska

Abstract

Grave's disease (GD) is a form of thyroid autoimmune disease characterised by hyperthyroidism. It is a rare clinical problem in paediatrics. Development of disease is the result of genetic susceptibility and some environmental factors. One of the best-documented environmental factors involved in thyroid autoimmunity is iodine excess. The aim of our study was to analyse the clinical course and response to pharmacological treatment in children diagnosed with Graves' disease in first two decades after mandatory salt iodination. Records of 94 children diagnosed with GD in the years 1998-2017 were analysed. Medical data of patients was compared between two decades following implementation of iodine prophylaxis: 1998-2007 (first-decade group - FDG) and 2008-2017 (second-decade group - SDG); 34 and 60 patients, respectively. Medical data of FDG was obtained from archival records and previous analysis performed in 2006. Data of 60 patients from SDG were obtained from currently available medical records. Results were statistically analysed using Microsoft Excel and Statistica 11 software. Results: In our study, after mandatory salt iodination, the tendency of an increase in newly diagnosed GD in children without family susceptibility wa...Continue Reading

Citations

Jul 6, 2019·Expert Opinion on Pharmacotherapy·Aleksandra KrólBarbara Jarzab
May 1, 2021·International Journal of Environmental Research and Public Health·Katarzyna AdamczewskaRenata Stawerska

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BETA
biopsy

Software Mentioned

Statistica
Excel

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