Graves' orbitopathy occurs sex-independently in an autoimmune hyperthyroid mouse model

Scientific Reports
Anke SchlüterU Berchner-Pfannschmidt

Abstract

Graves' orbitopathy (GO) is the most common extra thyroidal complication of Graves' disease (GD) and occurs predominantly in women but more severe in men. The reason for this effect of gender on GO is unknown. Herein we studied the manifestation of GO in both sexes of an induced mouse model in absence of additional risk factors present in patients like advanced age, genetic variabilities or smoking. Male and female mice were immunized with human TSHR A-subunit encoding plasmid. Both sexes comparably developed autoimmune hyperthyroidism characterized by TSHR stimulating autoantibodies, elevated T4 values, hyperplastic thyroids and hearts. Autoimmune mice developed inflammatory eye symptoms and proptosis, although males earlier than females. Serial in vivo 1H/19F-magnetic resonance imaging revealed elevated inflammatory infiltration, increased fat volume and glycosaminoglycan deposition in orbits of both sexes but most significantly in female mice. Histologically, infiltration of T-cells, extension of brown fat and overall collagen deposition were characteristics of GO in male mice. In contrast, female mice developed predominately macrophage infiltration in muscle and connective tissue, and muscle hypertrophy. Apart from sex-depe...Continue Reading

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Citations

May 14, 2020·Endocrine·A EcksteinU Berchner-Pfannschmidt
Jun 27, 2019·Thyroid : Official Journal of the American Thyroid Association·Svenja PlöhnUtta Berchner-Pfannschmidt
Nov 11, 2019·Chemico-biological Interactions·Hong LiYali Zhang
Feb 12, 2021·Frontiers in Immunology·Christine MölzerJohn V Forrester
Feb 18, 2021·Microbiome·Sajad MoshkelgoshaUNKNOWN INDIGO consortium
Mar 4, 2021·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Ming Hui LeeChin Meng Khoo
Nov 18, 2021·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Jiamin CaoWei Xiong

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Methods Mentioned

BETA
ELISA
transgenic
NMR

Software Mentioned

Graph Pad
CellProfiler
ImageJ
ParaVision

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