Gray and White Matter Contributions to Cognitive Frontostriatal Deficits in Non-Demented Parkinson's Disease

PloS One
Catherine C PriceDawn Bowers

Abstract

This prospective investigation examined: 1) processing speed and working memory relative to other cognitive domains in non-demented medically managed idiopathic Parkinson's disease, and 2) the predictive role of cortical/subcortical gray thickness/volume and white matter fractional anisotropy on processing speed and working memory. Participants completed a neuropsychological protocol, Unified Parkinson's Disease Rating Scale, brain MRI, and fasting blood draw to rule out vascular contributors. Within group a priori anatomical contributors included bilateral frontal thickness, caudate nuclei volume, and prefrontal white matter fractional anisotropy. Idiopathic Parkinson's disease (n = 40; Hoehn & Yahr stages 1-3) and non-Parkinson's disease 'control' peers (n = 40) matched on demographics, general cognition, comorbidity, and imaging/blood vascular metrics. Cognitively, individuals with Parkinson's disease were significantly more impaired than controls on tests of processing speed, secondary deficits on working memory, with subtle impairments in memory, abstract reasoning, and visuoperceptual/spatial abilities. Anatomically, Parkinson's disease individuals were not statistically different in cortical gray thickness or subcortical...Continue Reading

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Citations

Jun 7, 2016·The Clinical Neuropsychologist·Shannon M SiscoCatherine C Price
Apr 20, 2017·Frontiers in Aging Neuroscience·Haiqing HuangMingzhou Ding
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Jan 7, 2021·Journal of Pain Research·Yenisel Cruz-AlmeidaCatherine C Price
Mar 9, 2021·Journal of Parkinson's Disease·Catherine DionCatherine C Price

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Methods Mentioned

BETA
Blood Draw

Software Mentioned

TBSS
ITK
Brain Extraction Tool ( BET
FSLstats
FreeSurfer
ImageJ
SNAP
TRACULA
eddy
correct

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