Gray and white matter trajectories in patients with bipolar disorder

Bipolar Disorders
Gabriele SaniGianfranco Spalletta

Abstract

Findings on brain structural abnormalities in patients with bipolar disorder (BP) are inconsistent and little is known about age-related evolution of these changes. We employed a cross-sectional, case-control study to compare structural age-related brain trajectories in patients with BP and healthy control subjects (HC) over a period of approximately 50 years. The primary aim was to understand whether white (WM) and gray matter (GM) abnormalities are present from the beginning of the illness and how they change over time. Seventy-eight patients with BP and 78 HC matched for age, gender, and educational level underwent a high-resolution structural magnetic resonance imaging protocol. A voxel-based morphometry (VBM) analysis was used to capture GM and WM differences between subjects with BP and HC. Factorial analysis of covariance was used to compare brain volume alterations at different ages between the groups. We found an age-related atrophy in GM and WM volumes both in patients with BP and HC. A main effect of diagnosis emerged in the posterior cingulate cortex bilaterally, in the right thalamus, in the cerebellum bilaterally, and in the left posterior limb of the internal capsule. No interaction between diagnosis and age emer...Continue Reading

References

Nov 1, 1978·The British Journal of Psychiatry : the Journal of Mental Science·R C YoungD A Meyer
Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
Jan 1, 1987·Journal of Psychiatric Research·S W Lewis, R M Murray
Jul 1, 1987·Archives of General Psychiatry·D R Weinberger
Mar 1, 1994·The British Journal of Psychiatry : the Journal of Mental Science·G ParkerK Eyers
Jul 1, 1997·Journal of Psychiatric Research·J C Soares, J J Mann
Sep 24, 1999·Nature Neuroscience·J N GieddJ L Rapoport
Jun 20, 2002·Bipolar Disorders·John L Beyer, K Ranga R Krishnan
Jul 13, 2002·Biological Psychiatry·Melissa P López-LarsonStephen M Strakowski
Feb 1, 1960·Journal of Neurology, Neurosurgery, and Psychiatry·M HAMILTON
Mar 12, 2004·Biological Psychiatry·In Kyoon LyooPerry F Renshaw
Sep 2, 2004·Proceedings of the National Academy of Sciences of the United States of America·H Johansen-BergP M Matthews
Sep 2, 2004·Molecular Psychiatry·S M StrakowskiC M Adler
Sep 29, 2004·Biological Psychiatry·Roberto B SassiJair C Soares
Nov 24, 2004·Journal of Affective Disorders·Kevin A DavisRaymond F Deicken
May 3, 2005·The British Journal of Psychiatry : the Journal of Mental Science·Colm McDonaldRobin M Murray
Jun 16, 2005·NeuroImage·John Ashburner, Karl J Friston
Aug 2, 2005·The American Journal of Psychiatry·Neil P MillsStephen M Strakowski
Aug 24, 2005·Human Psychopharmacology·Franca CentorrinoRoss J Baldessarini
Sep 2, 2005·The American Journal of Psychiatry·Simerjit KaurJair C Soares
Oct 10, 2006·Biological Psychiatry·Caleb M AdlerStephen M Strakowski
Sep 1, 2007·NeuroImage·John Ashburner
Mar 12, 2008·Bipolar Disorders·Eduard Vieta, Trisha Suppes
Mar 19, 2008·European Archives of Psychiatry and Clinical Neuroscience·Harald ScherkOliver Gruber
Apr 11, 2008·Annals of the New York Academy of Sciences·Randy L BucknerDaniel L Schacter
Jun 17, 2008·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Benicio N FreyJair C Soares
Aug 9, 2008·Brain Research Reviews·Sylco S HoppenbrouwersZafiris J Daskalakis
Sep 3, 2008·Archives of General Psychiatry·Matthew J KemptonPaul M Grasby
Jan 16, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Katie MahonPhilip R Szeszko
Feb 19, 2009·Schizophrenia Bulletin·S Hossein Fatemi, Timothy D Folsom
May 22, 2009·NeuroImage·Jörn DiedrichsenNarender Ramnani
Jun 23, 2009·Journal of Affective Disorders·Yuan ZhouTianzi Jiang
Jul 15, 2009·Bipolar Disorders·Bruno EtainMarion Leboyer
Sep 2, 2009·The British Journal of Psychiatry : the Journal of Mental Science·Danilo ArnoneA M McIntosh
Nov 10, 2009·Neuroscience and Biobehavioral Reviews·Katie MahonPhilip R Szeszko
Sep 22, 2010·Social Cognitive and Affective Neuroscience·Marc G BermanJohn Jonides
Mar 25, 2011·Biological Psychiatry·Emma SprootenAndrew M McIntosh
Mar 17, 2012·Bipolar Disorders·Sudhakar SelvarajAndrew M McIntosh
Mar 20, 2012·Neurobiology of Disease·Sebastian WaltherThomas J Müller
Jul 11, 2012·Brain Structure & Function·Ellen GreimelSimon B Eickhoff

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Citations

Aug 5, 2017·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Christoph SchartnerAndreas Reif
Oct 26, 2018·Journal of Child and Adolescent Psychopharmacology·Simina TomaBenjamin I Goldstein
Apr 2, 2019·International Clinical Psychopharmacology·Giulio PerugiAlessandro Serretti
Jul 8, 2020·The Cerebellum·Frank Van OverwalleMaria Leggio
Jan 4, 2017·European Psychiatry : the Journal of the Association of European Psychiatrists·A C AltamuraP Brambilla
Apr 4, 2021·International Journal of Molecular Sciences·Michela LupoMaria Leggio

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Bipolar Disorder

Bipolar disorder is characterized by manic and/or depressive episodes and associated with uncommon shifts in mood, activity levels, and energy. Discover the latest research this illness here.