Gray matter anomalies in pedophiles with and without a history of child sexual offending

Translational Psychiatry
Boris SchifferHenrik Walter

Abstract

Pedophilia is a psychiatric disorder that is inter-related with but distinct from child sexual offending (CSO). Neural alterations reportedly contribute to both pedophilia and CSO, but until now, no study has distinguished the brain structural anomalies associated with pedophilia from those specifically associated with CSO in pedophilic men. Using high-resolution T1-weighted brain images and voxel-based morphometry, we analyzed the gray matter (GM) volume of the following 219 men recruited at four acquisition sites in Germany: 58 pedophiles with a history of CSO, 60 pedophiles without any history of CSO and 101 non-pedophilic, non-offending controls to control for the effects of age, education level, verbal IQ, sexual orientation and the acquisition site. Although there were no differences in the relative GM volume of the brain specifically associated with pedophilia, statistical parametric maps revealed a highly significant and CSO-related pattern of above vs below the 'normal' GM volume in the right temporal pole, with non-offending pedophiles exhibiting larger volumes than offending pedophiles. Moreover, regression analysis revealed that the lower GM volume of the dorsomedial prefrontal or anterior cingulate cortex was assoc...Continue Reading

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Citations

Feb 7, 2018·Frontiers in Human Neuroscience·Jorge PonsetiTillmann H C Kruger
May 27, 2020·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Florence ThibautUNKNOWN WFSBP Task Force on Paraphilias
Apr 7, 2018·European Psychiatry : the Journal of the Association of European Psychiatrists·Hannah GerwinnTillmann H C Kruger
Jan 20, 2019·Translational Psychiatry·Tillmann H C KrugerHelge Frieling
Feb 11, 2020·Frontiers in Psychiatry·Kirsten JordanJürgen Leo Müller
Jan 29, 2021·Brain Imaging and Behavior·Cristina ScarpazzaAndrea S Camperio Ciani
Feb 15, 2021·Journal of Chemical Neuroanatomy·Bastien HerlinSophie Dupont

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Software Mentioned

SPSS Statistics
MATLAB
VBM8
SPM8

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