Gray matter atrophy in dementia with Lewy bodies with and without concomitant Alzheimer's disease pathology

Neurobiology of Aging
Jessica J van der ZandeAfina W Lemstra

Abstract

We aimed to study if patients with dementia with Lewy bodies (DLB) who have concomitant Alzheimer's disease (AD) pathology (detected antemortem by cerebrospinal fluid [CSF] biomarkers) have additional loss of gray matter volume. Ninety-eight DLB patients were divided into a "pure DLB" (DLB/AD-, n = 62) and a "mixed DLB" group (DLB/AD+, n = 36) and matched for age and symptom duration to 84 AD patients and 75 controls. We compared visual atrophy ratings, and in a subset, we analyzed cortical thickness and subcortical gray matter volumes. DLB/AD+ patients had more pronounced medial temporal lobe atrophy (MTA) compared to DLB/AD- (mean [total] MTA score 2.5 vs. 1.3, p = 0.02). Global and parietal atrophy scores were comparable between the 3 dementia groups and differed from controls. MTA score was associated with CSF Aβ-42, while posterior cortical and global atrophy scores were associated with CSF tau. Cortical thinning was found in DLB/AD-, DLB/AD+, and AD compared to controls. Concomitant AD pathology seems to cause additional (hippocampal) atrophy in DLB, and this may contribute to a more devastating disease course in DLB/AD+ patients.

Citations

Sep 6, 2019·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·H S YooB S Ye
Feb 13, 2020·Movement Disorders : Official Journal of the Movement Disorder Society·Marleen van de BeekAfina W Lemstra
Feb 23, 2020·Annals of Neurology·Han Soo YooByoung Seok Ye
Aug 9, 2019·Journal of Neuroscience Research·Karina S VitanovaDamian M Cummings
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Feb 4, 2022·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Goichi BeckHideki Mochizuki

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