Gray Matter Volume and Resting-State Functional Connectivity of the Motor Cortex-Cerebellum Network Reflect the Individual Variation in Masticatory Performance in Healthy Elderly People

Frontiers in Aging Neuroscience
Chia-Shu LinHsien-Wei Ko

Abstract

Neuroimaging studies have consistently identified brain activation in the motor area and the cerebellum during chewing. In this study, we further investigated the structural and functional brain signature associated with masticatory performance, which is a widely used index for evaluating overall masticatory function in the elderly. Twenty-five healthy elderly participants underwent oral examinations, masticatory performance tests, and behavioral assessments, including the Cognitive Abilities Screening Instrument and the short-form Geriatric Depression Scale. Masticatory performance was assessed with the validated colorimetric method, using color-changeable chewing gum. T1-weighted structural magnetic resonance imaging (MRI) and resting-state function MRI were performed. We analyzed alterations in gray matter volume (GMV) using voxel-based morphometry and resting-state functional connectivity (rsFC) between brain regions using the seed-based method. The structural and functional MRI analyses revealed the following findings: (1) the GMV change in the premotor cortex was positively correlated with masticatory performance. (2) The rsFC between the cerebellum and the premotor cortex was positively correlated with masticatory perfor...Continue Reading

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Citations

Apr 20, 2017·Frontiers in Aging Neuroscience·Chia-Shu LinWen-Liang Lo
Jan 26, 2017·Frontiers in Neuroanatomy·Limor Avivi-ArberBarry J Sessle
Mar 15, 2020·Brain Imaging and Behavior·Chia-Shu LinJong-Ling Fuh
Apr 8, 2020·Frontiers in Aging Neuroscience·T KobayashiY Sahara
May 29, 2021·Advances in Geriatric Medicine and Research·Fritzie I Arce-McShane
Nov 19, 2021·Journal of Prosthodontic Research·Yoko KatoFumiyo Tamura

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Software Mentioned

SPM8
DARTEL ( Diffeomorphic Anatomical Registration Through Exponen...
Aquarelle Picker
Resting
- State fMRI Data Analysis Toolkit
Aquarelle

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