Gray matter volume reduction in obsessive-compulsive disorder with schizotypal personality trait

Progress in Neuro-psychopharmacology & Biological Psychiatry
Kyung Jin LeeJun Soo Kwon

Abstract

Obsessive-compulsive disorder (OCD) with schizotypal personality trait (SPT) and OCD without SPT demonstrated differences in cognitive dysfunction and treatment response. This study aimed to investigate whether brain volume differs between OCD with SPT and OCD without SPT. OCD with SPT (n=20), OCD without SPT (n=47), healthy comparison subjects (n=83) and schizophrenic patients (n=59) participated in this study. We assessed brain volume such as gray matter (GM), white matter (WM) and cerebrospinal fluid (CSF) using magnetic resonance imaging. The imaging data sets were filtered using anisotropic diffusion methods to improve the signal to noise ratio. The semi-automated region-growing method was used to remove images of tissues exterior to the brain. The fuzzy C-means algorithm was used to segment the extracted brain images into gray matter, white matter and cerebrospinal fluid. OCD with SPT (p=0.048) and Schizophrenic patients (p<0.001) demonstrated a significant GM volume reduction compared to healthy controls. OCD without SPT revealed no significant GM volume reduction compared to healthy controls (p=0.504). This study suggests that OCD with SPT could be distinguished as a distinct subtype of OCD, based on observations of gra...Continue Reading

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Citations

Mar 8, 2011·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Lung-Cheng HuangHai-Gwo Hwu
Nov 3, 2007·Progress in Neuro-psychopharmacology & Biological Psychiatry·Na Young ShinJun Soo Kwon
Aug 23, 2008·Biological Psychiatry·Jean-Yves RotgeBruno Aouizerate
Apr 18, 2014·The Australian and New Zealand Journal of Psychiatry·Vlasios BrakouliasKristy Mann
Feb 9, 2012·The Australian and New Zealand Journal of Psychiatry·Ji-Won HurJun Soo Kwon
Sep 23, 2010·Topics in Magnetic Resonance Imaging : TMRI·Leonardo F FontenelleChristos Pantelis
Feb 13, 2009·Expert Review of Neurotherapeutics·Jun Soo KwonDo-Hyung Kang
Apr 14, 2009·Topics in Magnetic Resonance Imaging : TMRI·David E FleckStephen M Strakowski
May 4, 2018·European Archives of Psychiatry and Clinical Neuroscience·Katharina BeyMichael Wagner

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