Gray matter volumes in symptomatic and asymptomatic offspring of parents diagnosed with bipolar disorder

European Child & Adolescent Psychiatry
Lindsay C HanfordRoberto B Sassi

Abstract

Children of parents diagnosed with bipolar disorder (BD), termed high-risk offspring (HRO), are at greater risk of developing psychiatric disorders compared to healthy children of healthy parents (HCO). Gray matter volume (GMV) abnormalities have been observed in HRO, however, these reports are inconsistent. We posit that this variability may be attributed to differences in methodology among offspring studies; in particular, the presence of psychiatric symptoms in HRO. Here, we directly compared GMVs between symptomatic and asymptomatic HRO, and HCO. High-resolution T1-weighted MR images were collected from 31 HRO (18 symptomatic and 13 asymptomatic) and 20 age- and sex-matched HCO. HRO had at least one parent diagnosed with BD. Symptomatic HRO were defined as having a psychiatric diagnosis other than BD, while asymptomatic HRO were required to be free of any psychiatric diagnosis. Scans were processed using voxel-based morphometry methods and between group analyses were performed in SPM. Compared to HCO, the HRO group showed decreased GMV in the right inferior orbitofrontal, right middle frontal, and bilateral superior and middle temporal regions. Both symptomatic and asymptomatic HRO groups showed decreased GMV in these regio...Continue Reading

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Citations

May 1, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Wenjing ZhangFabiano G Nery
Aug 4, 2020·Journal of the American Academy of Child and Adolescent Psychiatry·Manpreet K SinghDavid J Miklowitz

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