Gray whale transcriptome reveals longevity adaptations associated with DNA repair and ubiquitination.

Aging Cell
Dmitri TorenVadim E Fraifeld

Abstract

One important question in aging research is how differences in genomics and transcriptomics determine the maximum lifespan in various species. Despite recent progress, much is still unclear on the topic, partly due to the lack of samples in nonmodel organisms and due to challenges in direct comparisons of transcriptomes from different species. The novel ranking-based method that we employ here is used to analyze gene expression in the gray whale and compare its de novo assembled transcriptome with that of other long- and short-lived mammals. Gray whales are among the top 1% longest-lived mammals. Despite the extreme environment, or maybe due to a remarkable adaptation to its habitat (intermittent hypoxia, Arctic water, and high pressure), gray whales reach at least the age of 77 years. In this work, we show that long-lived mammals share common gene expression patterns between themselves, including high expression of DNA maintenance and repair, ubiquitination, apoptosis, and immune responses. Additionally, the level of expression for gray whale orthologs of pro- and anti-longevity genes found in model organisms is in support of their alleged role and direction in lifespan determination. Remarkably, among highly expressed pro-lon...Continue Reading

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Citations

Jan 28, 2021·International Journal of Molecular Sciences·Anton Y KulagaRobi Tacutu
Jun 4, 2021·Frontiers in Molecular Biosciences·Susanne HoltzeArne Sahm
May 30, 2021·Experimental Gerontology·Francisco Alejandro Lagunas-Rangel
May 15, 2021·DNA Research : an International Journal for Rapid Publication of Reports on Genes and Genomes·Xindan LiHao Du
Oct 12, 2021·Frontiers in Genetics·Kittisak BuddhachatKorakot Nganvongpanit
Aug 21, 2021·Annual Review of Genetics·Yang ZhaoVera Gorbunova

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Datasets Mentioned

BETA
SRR1685390
SRR919295
SRR2124226
GSM1698570
GSM219518
GSM1020723

Methods Mentioned

BETA
ubiquitination
biopsies

Software Mentioned

VSEARCH
Swiss
Trimmomatic
RNA Spades assembler
Trinity
TimeTree
BLAST
MEME Suite
GenAge
TopGO

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