Greasy tactics in the plant-pathogen molecular arms race

Journal of Experimental Botany
Patrick C Boyle, Gregory B Martin

Abstract

The modification of proteins by the attachment of fatty acids is a targeting tactic involved in mechanisms of both plant immunity and bacterial pathogenesis. The plant plasma membrane (PM) is a key battleground in the war against disease-causing microbes. This membrane is armed with an array of sensor proteins that function as a surveillance system to detect invading pathogens. Several of these sensor proteins are directed to the plasma membrane through the covalent addition of fatty acids, a process termed fatty acylation. Phytopathogens secrete effector proteins into the plant cell to subvert these surveillance mechanisms, rendering the host susceptible to infection. The targeting of effectors to specific locales within plant cells, particularly the internal face of the host PM, is critical for their virulence function. Several bacterial effectors hijack the host fatty acylation machinery to be modified and directed to this contested locale. To find and fight these fatty acylated effectors the plant leverages lipid-modified intracellular sensors. This review provides examples featuring how fatty acylation is a battle tactic used by both combatants in the molecular arms race between plants and pathogens. Also highlighted is th...Continue Reading

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Citations

Mar 1, 2015·Journal of Experimental Botany·Charlotte H Hurst, Piers A Hemsley
Oct 27, 2016·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Zhenyu Cheng
Oct 13, 2017·FEBS Letters·Chunxia ZhangOliver Batistič
Jun 30, 2019·Molecular Plant-microbe Interactions : MPMI·Robyn RobertsGregory B Martin
Apr 7, 2021·Chemical Reviews·Kiall F SuazoMark D Distefano

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