Greater BOLD variability in older compared with younger adults during audiovisual speech perception

PloS One
Sarah H Baum, Michael S Beauchamp

Abstract

Older adults exhibit decreased performance and increased trial-to-trial variability on a range of cognitive tasks, including speech perception. We used blood oxygen level dependent functional magnetic resonance imaging (BOLD fMRI) to search for neural correlates of these behavioral phenomena. We compared brain responses to simple speech stimuli (audiovisual syllables) in 24 healthy older adults (53 to 70 years old) and 14 younger adults (23 to 39 years old) using two independent analysis strategies: region-of-interest (ROI) and voxel-wise whole-brain analysis. While mean response amplitudes were moderately greater in younger adults, older adults had much greater within-subject variability. The greatly increased variability in older adults was observed for both individual voxels in the whole-brain analysis and for ROIs in the left superior temporal sulcus, the left auditory cortex, and the left visual cortex. Increased variability in older adults could not be attributed to differences in head movements between the groups. Increased neural variability may be related to the performance declines and increased behavioral variability that occur with aging.

References

Dec 20, 2015·Experimental Aging Research·Stefanie E KuchinskyMark A Eckert
Apr 14, 2020·The European Journal of Neuroscience·James HigginsTodd Parrish
Jun 5, 2018·Current Behavioral Neuroscience Reports·Sarah H Baum, Ryan Stevenson
Mar 28, 2019·Frontiers in Aging Neuroscience·Daiana R PurSandrine de Ribaupierre

Citations

Jan 10, 1992·Science·A K JonesR S Frackowiak
Aug 1, 1990·The Journal of the Acoustical Society of America·L J Brant, J L Fozard
Jul 1, 1984·The Journal of the Acoustical Society of America·J R DubnoD E Morgan
May 1, 1995·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·S D FormanD C Noll
Aug 1, 1994·Acta Psychologica·J Cerella, S Hale
Jun 1, 1996·Computers and Biomedical Research, an International Journal·Robert W Cox
Mar 22, 2000·Nature Neuroscience·M T SchmoleskyAudie G Leventhal
Sep 29, 2000·The Journal of the Acoustical Society of America·K W Grant, P F Seitz
Sep 8, 2001·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·J MazziottaB Mazoyer
Oct 31, 2001·Trends in Cognitive Sciences·Shu-Chen LiSverker Sikström
Feb 28, 2002·The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences·David F HultschRoger A Dixon
Mar 1, 1963·Journal of Speech and Hearing Research·L L PRICE
Dec 5, 2003·Cerebral Cortex·Bruce FischlAnders Dale
Jan 22, 2004·Nature Reviews. Neuroscience·Trey Hedden, John D E Gabrieli
Nov 16, 2004·Trends in Neurosciences·David C Knill, Alexandre Pouget
Jul 22, 2005·Human Brain Mapping·Brenna D ArgallMichael S Beauchamp
Sep 15, 2005·The Journal of the Acoustical Society of America·Pierre L DivenyiKara M Haupt
Nov 22, 2005·Neurobiology of Aging·Tianmiao HuaAudie G Leventhal
Mar 15, 2006·PLoS Biology·Daniel A Butts, Mark S Goldman
Apr 26, 2006·NeuroImage·Rebecca SaxeNancy Kanwisher
Apr 26, 2006·NeuroImage·K J FristonR N Henson
Oct 24, 2006·Nature Neuroscience·Wei Ji MaAlexandre Pouget
Dec 14, 2006·Neuropsychology, Development, and Cognition. Section B, Aging, Neuropsychology and Cognition·Kelly J MurphyDonald T Stuss
Aug 5, 2008·Neurobiology of Aging·Zhen LiangAudie G Leventhal
Nov 6, 2008·Social Cognitive and Affective Neuroscience·Russell A Poldrack
Apr 21, 2009·Brain Research·Yun YangYifeng Zhou
Apr 28, 2009·Nature Neuroscience·Nikolaus KriegeskorteChris I Baker
Jan 29, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Gregory R Samanez-LarkinBrian Knutson
Feb 4, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Audrey R Nath, Michael S Beauchamp
Mar 25, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Douglas D GarrettCheryl L Grady
Jul 7, 2011·Ear and Hearing·Samira AndersonNina Kraus
Aug 4, 2011·NeuroImage·Koene R A Van DijkRandy L Buckner
Sep 16, 2011·International Journal of Audiology·Penny Anderson Gosselin, Jean-Pierre Gagné
Dec 3, 2011·Journal of Clinical and Experimental Neuropsychology·Po H LuGeorge Bartzokis
Jun 16, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Stuart W S MacDonaldLars Bäckman
Sep 25, 2012·NeuroImage·Martin LövdénNaftali Raz

Related Concepts

Mini-mental State Examination
Entire Brain
Syllable
Magnetic Resonance Imaging
Planum Temporale
Blood Vessel
Neurons
Blurred Vision
Brain
Visual Perception

Related Feeds

Brain Aging

Here is the latest research on intrinsic and extrinsic factors, as well as pathways and mechanisms that underlie aging in the central nervous system.

Cell Aging

This feed focuses on cellular aging with emphasis on the mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

Auditory Perception

Auditory perception is the ability to receive and interpret information attained by the ears. Here is the latest research on factors and underlying mechanisms that influence auditory perception.

Cell Aging (Keystone)

This feed focuses on cellular aging with emphasis on the mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.