PMID: 9160277Apr 1, 1997Paper

Greater emotional distress is associated with accelerated CD4+ cell decline in HIV infection

Journal of Psychosomatic Research
K VedharaA T Nayagam

Abstract

An investigation was conducted to explore the relationship between emotional distress and HIV progression. One hundred twenty-five homosexual, HIV-positive males participated in a 12-month longitudinal investigation. Psychosocial data were collected at 6-month intervals and CD4+ data were collected from diagnosis to the end of the investigation. Principal component analyses were performed initially to identify factors of emotional distress and health status. In addition, CD4+ reliability assessments were performed to ensure the validity of the prognostic assessments made. As a result of these analyses, 47 individuals were eligible for the main analyses. The results from a stepwise regression revealed that disease progression was significantly predicted by CD4+ count at diagnosis (32% of variance) and emotional distress (17% of variance), but was unrelated to subjective perceptions of health. The data suggest that some of the variability in HIV progression can be attributed to emotional distress.

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Citations

Aug 23, 2011·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Jeffrey S GonzalezSteven A Safren
Feb 22, 2000·Annals of the New York Academy of Sciences·L C Gallo, K A Matthews
May 13, 2010·AIDS Care·Sarah AbboudJacques Mokhbat
Jul 25, 2000·Baillière's Best Practice & Research. Clinical Endocrinology & Metabolism·E G BalbinG F Solomon
Jul 23, 2014·Journal of Immigrant and Minority Health·Leonid KapulskyJanet E Forrester

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