Greater eosinophil counts at first COPD hospitalization are associated with more readmissions and fewer deaths

International Journal of Chronic Obstructive Pulmonary Disease
Qing LiAlain Vanasse

Abstract

The impacts of high blood eosinophil count (HBEC) at admission for COPD exacerbation on posthospitalization outcomes are still unclear. Previous studies have focused on its associations with first readmission rates; yet, its impacts on longitudinal outcomes such as subsequent readmissions still have to be explored. The main objective of this study is to investigate outcomes associated with HBEC following a first hospitalization for COPD exacerbation. This is an observational cohort study design. We retrospectively analyzed data of patients with a first hospitalization within 5 years for COPD exacerbation between April 2006 and March 2013. Patients were stratified into the HBEC group if the blood eosinophil count at admission was ≥200 cells/µL and/or ≥2% of the total white blood cells. With information on exact dates of subsequent hospitalizations and death, we modeled readmissions and death as states in a multi-state Markov model and estimated transition probabilities to the next states. Sensitivity analyses were performed by varying thresholds for the definition of HBEC (≥300 cells/µL and/or ≥3%). A total of 479 patients were included, of which 173 had HBEC. The transition probabilities for a first readmission was 74% (95% CI,...Continue Reading

Citations

Dec 10, 2019·The Clinical Respiratory Journal·Stanca-Patricia HogeaCristian Oancea
Jun 18, 2020·International Journal of Chronic Obstructive Pulmonary Disease·Ying ZhangYing-Xiang Lin
Sep 19, 2020·International Journal of Chronic Obstructive Pulmonary Disease·Jung-Ki YoonDeog Kyeom Kim
Apr 21, 2020·International Journal of Chronic Obstructive Pulmonary Disease·Kjell E J HåkanssonLine J H Rasmussen
Mar 12, 2021·ERJ Open Research·Marjan KerkhofDavid B Price
Oct 13, 2020·The American Journal of Emergency Medicine·Yasemin KandemirSerkan Yılmaz

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