Greater externalizing personality traits predict less error-related insula and anterior cingulate cortex activity in acutely abstinent cigarette smokers

Addiction Biology
Allison J CarrollElliot A Stein

Abstract

Attenuated activity in performance-monitoring brain regions following erroneous actions may contribute to the repetition of maladaptive behaviors such as continued drug use. Externalizing is a broad personality construct characterized by deficient impulse control, vulnerability to addiction and reduced neurobiological indices of error processing. The insula and dorsal anterior cingulate cortex (dACC) are regions critically linked with error processing as well as the perpetuation of cigarette smoking. As such, we examined the interrelations between externalizing tendencies, erroneous task performance, and error-related insula and dACC activity in overnight-deprived smokers (n = 24) and non-smokers (n = 20). Participants completed a self-report measure assessing externalizing tendencies (Externalizing Spectrum Inventory) and a speeded Flanker task during functional magnetic resonance imaging scanning. We observed that higher externalizing tendencies correlated with the occurrence of more performance errors among smokers but not non-smokers. Suggesting a neurobiological contribution to such suboptimal performance among smokers, higher externalizing also predicted less recruitment of the right insula and dACC following error commis...Continue Reading

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Citations

May 23, 2015·Addiction Biology·Rick E Bernardi
Jun 17, 2016·Pharmacology, Biochemistry, and Behavior·Mounir Ouzir, Mohammed Errami
Aug 16, 2016·Frontiers in Neuroscience·Samantha V AbramNiels G Waller
Feb 5, 2016·Brain Imaging and Behavior·Yanzhi BiJie Tian
Jan 30, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·E LesageE A Stein
Jul 21, 2016·Brain Imaging and Behavior·Yangding LiJie Tian
Aug 3, 2020·Brain Imaging and Behavior·Allison J LakeThomas W James
Aug 21, 2020·Cognitive, Affective & Behavioral Neuroscience·M E Van der SluysR Marhe
Mar 13, 2021·NeuroImage·Ruiyang GeFidel Vila-Rodriguez
Apr 3, 2021·Clinical Psychology Review·Giorgia MicheliniRoman Kotov

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