Greater hypertrophy in right than left ventricles is associated with pulmonary vasculopathy in sinoaortic-denervated Wistar-Kyoto rats

Clinical and Experimental Pharmacology & Physiology
Chao-Yu MiaoDing-Feng Su

Abstract

1. Biventricular hypertrophy has been described in a high blood pressure variability (BPV) model of sinoaortic-denervated (SAD) rats without systemic hypertension. To explore the possible involvement of the lung in SAD-induced right ventricular hypertrophy (RVH), we examined lung morphology, in addition to systemic haemodynamics and ventricle morphology, in Wistar-Kyoto rats 32 weeks after SAD. 2. In Wistar-Kyoto rats 32 weeks after SAD, there existed a substantial elevation in BPV, with no change in the average level of arterial pressure. Biventricular hypertrophy following SAD was characterized by a greater hypertrophy in right than left ventricles; both absolute and normalized right ventricular weights were significantly increased by 22 and 27%, respectively, and only normalized left ventricular weight was significantly increased by 12%. No infarcts were found in any ventricles examined. 3. In the lung, the most prominent change following SAD was pulmonary vasculopathy, including wall thickening, perivascular fibrosis and cell infiltration. In pulmonary arteries with an internal diameter of 70-130 microm, the external diameter, wall thickness and wall thickness to internal diameter ratio were increased in SAD compared with c...Continue Reading

References

Feb 4, 1999·Hypertension·J M VanNessJ R Haywood
Apr 27, 2000·American Journal of Physiology. Lung Cellular and Molecular Physiology·J I AguirreM R Wilkins
Dec 29, 2000·Clinical and Experimental Hypertension : CHE·B N Van Vliet, L L Chafe
Dec 12, 2001·American Journal of Physiology. Renal Physiology·Silene L S PiresChristian Barrès
Jan 28, 2003·Journal of Cardiovascular Pharmacology·He-Hui XieDing-Feng Su
May 17, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Reda E GirgisRoger A Johns
Jul 10, 2003·American Journal of Hypertension·Chao-Yu MiaoDing-Feng Su
Dec 1, 1964·Circulation Research·E M KRIEGER

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Citations

May 24, 2005·Atherosclerosis·Guo-Jun CaiDing-Feng Su
Jun 23, 2006·Clinical and Experimental Pharmacology & Physiology·Xiao-Wen GuDing-Feng Su
May 12, 2010·Clinical and Experimental Pharmacology & Physiology·Pei WangChao-Yu Miao
May 10, 2011·European Journal of Pharmacology·Jinzhong FengFeng Wu
Nov 15, 2011·Autonomic Neuroscience : Basic & Clinical·K FluesE G Caldini
Sep 9, 2008·Journal of Pharmacological Sciences·Jian-Guang YuDing-Feng Su
Nov 25, 2005·Journal of Cardiovascular Pharmacology·Li-Hua LuDing-Feng Su

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