Greater influence of age than co-morbidity on primary treatment and complications of prostate cancer patients: an in-depth population-based study

Prostate Cancer and Prostatic Diseases
S HoutermanJ W Coebergh

Abstract

We investigated the influence of age and co-morbidity on treatment, the occurrence of serious non-urological complications of treatment and prognosis for prostate cancer patients diagnosed and treated in community hospitals. Additional information from a random sample of 505 prostate cancer patients (aged 40 years or older) from the Eindhoven Cancer Registry diagnosed between 1995 and 1999 was collected. In all, 43% of the prostate cancer patients aged 40-69 years and 64% of those aged 70 or older suffered from one or more serious concomitant disease that barely affected primary treatment choice. However, compared to patients without co-morbidity, patients with cardiovascular diseases underwent radical prostatectomy less often (P=0.01). In all, 38% of the patients undergoing radical prostatectomy suffered from complications during the first year after diagnosis versus about 20% of those receiving radiotherapy. The number of complications did not seem to be affected by co-morbidity. After adjustment for age, stage, grade, prostate-specific antigen level and treatment, the cumulative risk of death was almost two times higher for patients with two or more concomitant diseases than for patients without co-morbidity. After adjustmen...Continue Reading

References

Jun 1, 1993·International Journal of Epidemiology·L J SchoutenJ J Jager
May 1, 1997·The Journal of Urology·O DillioglugilP T Scardino
Dec 26, 2001·Journal of the National Cancer Institute·L C HarlanR A Stephenson
Nov 7, 2003·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·S SieslingUNKNOWN Working Group of The Netherlands Cancer Registry
Nov 20, 2003·Urology·Kevin L SchwartzMurray D Krahn
May 27, 2004·JAMA : the Journal of the American Medical Association·Jay F PiccirilloEdward L Spitznagel
Oct 11, 2005·Critical Reviews in Oncology/hematology·S HoutermanJ W W Coebergh
Oct 20, 2005·Journal of the National Cancer Institute·Shabbir M H AlibhaiGary Naglie

❮ Previous
Next ❯

Citations

Jul 14, 2010·American Journal of Clinical Oncology·Antonella BrunelloMartine Extermann
Oct 4, 2012·The Oncologist·Heather A Payne, Simon Hughes
Mar 29, 2014·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·M NdoyeS Gueye
Feb 9, 2010·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A G PallisH Wildiers
Nov 3, 2009·Urologic Oncology·Ajay Sandhu, Arno J Mundt
Nov 3, 2009·Urologic Oncology·Hans Heinzer, Thomas Steuber
Oct 20, 2009·Critical Reviews in Oncology/hematology·Jean-Pierre DrozCora N Sternberg
Apr 24, 2015·Scandinavian Journal of Urology·Christina G JespersenMichael Borre
Mar 17, 2015·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Benjamin HagerJohannes Huber
Oct 12, 2010·International Journal of Radiation Oncology, Biology, Physics·Thomas WahlgrenYvonne Brandberg
Aug 22, 2009·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·T D NguyenR C Miller
Jul 30, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Arti HurriaUNKNOWN Cancer and Aging Research Group
May 10, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Martine Extermann, Arti Hurria
Nov 16, 2018·International Journal of Radiation Biology·Daniela StricklinJacob Bellman
Sep 27, 2008·Journal of Oral Science·Kaan GündüzPinar Sümer
Jun 1, 2017·American Society of Clinical Oncology Educational Book·Alicia K MorgansAlberto Briganti
Mar 29, 2014·International Journal of Biometeorology·Magdalena SadyśRoy Kennedy
Aug 2, 2017·International Urology and Nephrology·Valentin BrodszkyLászló Gulácsi
Jun 7, 2017·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Xiao-Jun LiuXu-Dong Yao

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Shabbir M H AlibhaiMurray D Krahn
The Journal of Urology
Ian ThompsonAUA Prostate Cancer Clinical Guideline Update Panel
© 2021 Meta ULC. All rights reserved