Greater loop chloride uptake contributes to blunted pressure natriuresis in Dahl salt sensitive rats.

Journal of the American Society of Nephrology : JASN
K A Kirchner

Abstract

A blunted pressure natriuretic response is present in Dahl salt sensitive rats. To determine whether this results from tubular or glomerular mechanisms, late proximal, early distal, and late distal micropuncture were performed in salt resistant (R), salt sensitive (S), or salt sensitive rats with renal perfusion reduced to that of R rats (S-AC). Differences in neuro-endocrine background between groups were eliminated by renal denervation and by fixing plasma aldosterone, norepinephrine, and vasopressin levels by infusion. Renal perfusion pressure was greater (P less than 0.05) and inulin clearance less (P less than 0.05) in S than R rats. Urinary sodium excretion, however, was not different. S-AC had renal perfusion pressures that were similar to R rats and inulin clearance similar to S rats. Urinary NaCl excretion was less (P less than 0.05) than either group. Single nephron inulin clearance, fluid, and chloride delivery to late proximal sites were not different between groups. Absolute and fractional chloride delivery to early distal sites was less (P less than 0.05) in S-AC than R or S but not different between R and S. Late distal chloride delivery was not different between any group. Calculated loop chloride reabsorption w...Continue Reading

Citations

Feb 13, 2021·Nature Communications·Zhongmin Tian, Mingyu Liang
Jun 12, 2002·Biochemical and Biophysical Research Communications·Akira IkariYasunobu Suketa
Feb 7, 1998·Hypertension·T W WilsonR J Roman
Feb 7, 1998·Hypertension·M Alonso-GaliciaR J Roman
Jan 7, 2006·American Journal of Physiology. Renal Physiology·Richard J RomanAlbert Sarkis
Oct 12, 2010·Journal of Cardiovascular Pharmacology·Jan M WilliamsRichard J Roman
Sep 9, 2011·American Journal of Physiology. Renal Physiology·Gustavo R AresPablo A Ortiz

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.