Abstract
A blunted pressure natriuretic response is present in Dahl salt sensitive rats. To determine whether this results from tubular or glomerular mechanisms, late proximal, early distal, and late distal micropuncture were performed in salt resistant (R), salt sensitive (S), or salt sensitive rats with renal perfusion reduced to that of R rats (S-AC). Differences in neuro-endocrine background between groups were eliminated by renal denervation and by fixing plasma aldosterone, norepinephrine, and vasopressin levels by infusion. Renal perfusion pressure was greater (P less than 0.05) and inulin clearance less (P less than 0.05) in S than R rats. Urinary sodium excretion, however, was not different. S-AC had renal perfusion pressures that were similar to R rats and inulin clearance similar to S rats. Urinary NaCl excretion was less (P less than 0.05) than either group. Single nephron inulin clearance, fluid, and chloride delivery to late proximal sites were not different between groups. Absolute and fractional chloride delivery to early distal sites was less (P less than 0.05) in S-AC than R or S but not different between R and S. Late distal chloride delivery was not different between any group. Calculated loop chloride reabsorption w...Continue Reading
Citations
Sep 15, 2012·The Journal of Biological Chemistry·Gustavo R Ares, Pablo A Ortiz
Feb 13, 2021·Nature Communications·Zhongmin Tian, Mingyu Liang
Apr 2, 2021·Scientific Reports·Nadezhda N ZheleznovaAllen W Cowley
Dec 9, 1998·Kidney International·J E TankW L Henrich
Jun 12, 2002·Biochemical and Biophysical Research Communications·Akira IkariYasunobu Suketa
Mar 8, 2003·Hypertension·Hiroyuki KoboriL Gabriel Navar
Dec 24, 2019·Hypertension·Fara SaezJeffrey L Garvin
Jan 1, 1997·Hypertension·D E StecR J Roman
Feb 7, 1998·Hypertension·T W WilsonR J Roman
Feb 7, 1998·Hypertension·M Alonso-GaliciaR J Roman
Sep 18, 1999·Hypertension·N H GarcíaJ L Garvin
Dec 1, 1993·Hypertension·A PatelK A Kirchner
Mar 1, 1996·Hypertension·D E StecR J Roman
Mar 1, 1996·Hypertension·A P ZouR J Roman
Feb 4, 1999·Hypertension·O Ito, R J Roman
Dec 1, 1995·Hypertension·Y IkedaM Yokoyama
Jun 1, 1991·Hypertension·R J Roman, M L Kaldunski
Jul 11, 2012·Hypertension·Nancy J Hong, Jeffrey L Garvin
Oct 31, 2012·Hypertension·Gustavo R AresPablo A Ortiz
Nov 28, 2012·Hypertension·Chun YangAllen W Cowley
Dec 21, 2005·Hypertension·Youping Wang, Donna H Wang
Jan 7, 2006·American Journal of Physiology. Renal Physiology·Richard J RomanAlbert Sarkis
Jul 1, 1993·Kidney International·C T Hawk, J A Schafer
Mar 31, 2021·Journal of Hypertension·Yang WangJian-Jun Mu
Oct 9, 1998·Clinical and Experimental Hypertension : CHE·X WuH Sonnenberg
Oct 12, 2010·Journal of Cardiovascular Pharmacology·Jan M WilliamsRichard J Roman
Sep 9, 2011·American Journal of Physiology. Renal Physiology·Gustavo R AresPablo A Ortiz