Greater magnitude of turnover suppression occurs earlier after treatment initiation with risedronate than alendronate

Bone
Matthew R AllenDavid B Burr

Abstract

Clinical data suggest that reductions in fractures associated with osteoporosis may occur sooner in patients treated with risedronate (RIS) compared to those treated with alendronate (ALN). This could be explained by differences in the time course of turnover suppression between these two bisphosphonates. To determine if differences in the onset of turnover suppression exist between RIS and ALN, female New Zealand white rabbits (total n=32) were treated with clinically relevant doses of RIS or ALN and then administered different fluorochrome labels weekly for four weeks in order to allow histological assessment of the time-course of turnover suppression. By the third week of treatment vertebral trabecular bone formation rate (BFR/BS) was significantly suppressed with RIS-treatment compared to both VEH and ALN. By the 4th week of treatment, turnover rates in RIS-treated animals remained significantly lower than in VEH-treated animals and were also lower than ALN; at this time-point ALN was significantly lower than VEH. There was no significant reduction in intra-cortical remodeling in the tibial mid-diaphysis at any time point for either RIS or ALN. This greater effect on turnover suppression with RIS early in treatment compared...Continue Reading

References

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May 10, 2008·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Robyn K FuchsDavid B Burr

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Citations

Dec 25, 2012·Clinical Oral Investigations·Hechang HuangDo-Gyoon Kim
May 31, 2014·BoneKEy Reports·Michael PazianasPaul Miller
Nov 13, 2015·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·E Seeman, T V Nguyen
Feb 17, 2015·Bone·Andrew P BaumannRyan K Roeder
Jul 10, 2014·Journal of Bone Metabolism·Do-Gyoon Kim
Sep 22, 2018·Frontiers in Endocrinology·Sabashini K Ramchand, Ego Seeman
Nov 2, 2019·Dento Maxillo Facial Radiology·Édila Figuerêdo FeitosaSandra Regina Torres
Nov 6, 2018·Progress in Orthodontics·Sumit YadavAditya Tadinada
Nov 27, 2020·Frontiers in Veterinary Science·Silvia Fernández-MartínAntonio González-Cantalapiedra

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