Greater Neonatal Fat-Free Mass and Similar Fat Mass Following a Randomized Trial to Control Excess Gestational Weight Gain

Obesity
Dympna GallagherXavier Pi-Sunyer

Abstract

The objective of this study was to determine the effectiveness of controlling maternal gestational weight gain (GWG) in the second and third trimesters on neonate body composition. Two hundred ten healthy women with overweight (25 > BMI < 30) or obesity (BMI ≥ 30) were randomly assigned to a lifestyle intervention (LI) program focused on controlling GWG through nutrition and activity behaviors or to usual obstetrical care (UC). Infant fat and fat-free mass (FFM) at birth were measured by using air displacement plethysmography (PEA POD) and by using quantitative magnetic resonance (QMR). At baseline, there were no between-group differences in maternal characteristics (mean [SD]): age: 33.8 (4.3) years, weight: 81.9 (13.7) kg, BMI: 30.4 (4.5), and gestational age at randomization: 14.9 (0.8) weeks. GWG was less in the LI group by 1.79 kg (P = 0.003) or 0.0501 kg/wk (P = 0.002). Compared with UC infants, LI infants had greater weight (131 ± 59 g P = 0.03), FFM (98 ± 45 g; P = 0.03) measured by PEA POD, and lean mass (105 ± 38 g; P = 0.006) measured by QMR. Fat mass and percent fat were not significantly different. Intervening in women with overweight and obesity through behaviors promoting healthy diet and physical activity to con...Continue Reading

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Citations

Aug 2, 2019·The Journal of Clinical Investigation·Jasper MostLeanne M Redman
Jul 12, 2019·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Suzanne PhelanUNKNOWN LIFE-Moms Research Group
Dec 21, 2019·The Journal of Nutrition·Rebecca KuriyanAnura V Kurpad
Jul 28, 2019·Scientific Reports·Claudiu MărgineanClaudia Bănescu
Nov 26, 2020·Diabetes Research and Clinical Practice·Leanne M RedmanUNKNOWN LIFE-Moms Research Group
Sep 25, 2021·Pediatric Obesity·Mahalakshmi GopalakrishnamoorthyDympna Gallagher

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Clinical Trials Mentioned

NCT01616147

Software Mentioned

PEAPOD
STATA
UPBEAT
Moms
LIFT
SAS
EchoMRI

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