Greater occipital nerve blockade for the treatment of chronic migraine: a randomized, multicenter, double-blind, and placebo-controlled study

Acta Neurologica Scandinavica
L E InanA Akyol

Abstract

We aimed to assess the efficacy of greater occipital nerve (GON) blockade at chronic migraine (CM) treatment. Patients with CM were randomly divided into two groups of 42. GON blockade was administered four times (once per week) with saline in group A or bupivacaine in group B. After 4 weeks of treatment, blinding was removed; in group A, GON blockade was achieved using bupivacaine, while group B continued to receive bupivacaine, and blockade was administered once per month, then followed for 2 months. Primary endpoint was the difference in number of headache days, duration of headache, and pain scores. Seventy-two of 84 patients completed the study. After 1 month of treatment, number of headache days had decreased from 16.9 ± 5.7 to 13.2 ± 6.7 in group A (P = 0.035) and from 18.1 ± 5.3 to 8.8 ± 4.8 in group B (P < 0.001), (P = 0.004, between groups); duration of headache (hour) had decreased from 24.2 ± 13.7 to 21.2 ± 13.4 in group A (P = 0.223) and from 25.9 ± 16.3 to 19.3 ± 11.5 in group B (P < 0.001), (P = 0.767, between groups). VAS score decreased from 8.1 ± 0.9 to 6.7 ± 1.6 in group A (P = 0.002) and from 8.4 ± 1.5 to 5.3 ± 2.1 in group B (P < 0.001), (P = 0.004, between groups). After blinding was removed (in 2nd and 3r...Continue Reading

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Citations

Feb 15, 2016·Current Pain and Headache Reports·Aynur Özge, Osman Özgür Yalin
Jan 3, 2016·Clinical Neurology and Neurosurgery·Elisabeth FarbuSigurbjørg Stefansdottir
Apr 9, 2016·SpringerPlus·Ya-Nan LuYu Wang
Mar 10, 2016·Expert Review of Neurotherapeutics·Paolo MartellettiDimos-Dimitrios Mitsikostas
Apr 29, 2015·Headache·Andrew BlumenfeldRandolph W Evans
Aug 20, 2015·Current Pain and Headache Reports·Amaal J Starling, Bert B Vargas
Jun 28, 2016·Neurología : publicación oficial de la Sociedad Española de Neurología·S Santos LasaosaJ A Pareja
Jul 9, 2016·Nature Reviews. Neurology·Arne May, Laura H Schulte
Aug 1, 2016·Oral and Maxillofacial Surgery Clinics of North America·Jonathan K Kleen, Morris Levin
Jun 12, 2016·Cephalalgia : an International Journal of Headache·María L CuadradoJosé A Arias
Jun 15, 2016·Cephalalgia : an International Journal of Headache·María L CuadradoCristina Fernández-Pérez
May 15, 2018·Headache·Joshua Kamins, Andrew Charles
Nov 11, 2017·Current Pain and Headache Reports·Alexander Sasha Dubrovsky
Sep 28, 2017·The Journal of Headache and Pain·Kerstin Luedtke, Arne May
Aug 7, 2018·The Journal of Comparative Neurology·Nuria García-MagroCarlos Avendaño
Jan 8, 2019·Cephalalgia : an International Journal of Headache·Levent Ertugrul InanGulcin Babaoglu
Feb 14, 2016·Cephalalgia : an International Journal of Headache·Levent Ertugrul Inan
Mar 15, 2019·Current Pain and Headache Reports·Amir RashedAli Pourmand
May 2, 2019·Cephalalgia : an International Journal of Headache·Marie DeenHsiangkuo Yuan
May 6, 2019·Expert Review of Neurotherapeutics·János TajtiLászló Vécsei
Oct 4, 2019·British Journal of Neurosurgery·Mark W Weatherall, Dipankar Nandi
May 4, 2016·Current Opinion in Anaesthesiology·Michele Curatolo
Aug 25, 2019·The Journal of Headache and Pain·Linda D'Antona, Manjit Matharu
Mar 2, 2017·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Hanzade Aybüke Ünal-ArtıkTahir Kurtuluş Yoldaş
Jan 29, 2019·Military Medicine·Karen A WilliamsJohn D Coppin
May 16, 2019·Cephalalgia : an International Journal of Headache·Sarah MillerManjit Matharu
Sep 9, 2017·AJNR. American Journal of Neuroradiology·L HwangA Chhabra
Nov 18, 2020·Cephalalgia : an International Journal of Headache·Gabriela F CarvalhoArne May

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