PMID: 701845Oct 1, 1978Paper

Greater promotion in sister chromatid exchanges by trimethylpsoralen than by 8-methoxypsoralen in the presence of UV-light

The Journal of Investigative Dermatology
A L Gaynor, D M Carter

Abstract

The number of sister chromatid exchanges (SCEs) was determined in normal human leukocytes following exposure in vitro to UV light (365 nm, UV-A) and either 8-methoxypsoralen (8-MOP) or 4,5'8 trimethylpsoralen (TMP). Both psoralens produced an increase in SCEs, proportional to UV dose and concentration of drug. Neither drug alone nor UV alone promoted SCEs. The number of SCEs per cell was greater in leukocytes irradiated in the presence of TMP than in the presence of equimolar 8-MOP. At equimolar concentrations, TMP formed more cross-links than did 8-MOP. The difference in the effects of these 2 agents on various cell functions may relate to quantitative and qualitative differences in the photoadducts they form.

References

Oct 1, 1977·The Journal of Investigative Dermatology·E C Wolff-SchreinerK Wolff
Oct 1, 1976·The Journal of Investigative Dermatology·D M CarterW Schnedl
Oct 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·S A LattP S Gerald
Nov 28, 1975·Deutsche medizinische Wochenschrift·K WolffK Konrad
Aug 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·S A Latt
Dec 5, 1974·The New England Journal of Medicine·J A ParrishM A Pathak
Apr 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·R S Cole
Apr 1, 1953·The Journal of Investigative Dermatology·A B LERNERT B FITZPATRICK

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Citations

Dec 1, 1980·Photochemistry and Photobiology·B J Parsons
Jan 1, 1982·Archives of Dermatological Research·D M CarterD B Windhorst
Sep 1, 1980·International Journal of Dermatology·J A ParrishT B Fitzpatrick
Jul 1, 1981·Mutation Research·S A LattS Wolff

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