Green and efficient extraction of four bioactive flavonoids from Pollen Typhae by ultrasound-assisted deep eutectic solvents extraction

Journal of Pharmaceutical and Biomedical Analysis
Zhaorui MengLongshan Zhao

Abstract

Recently, deep eutectic solvents (DESs) have been recognized as a novel class of sustainable solvents to replace common organic solvents. In this study, a highly and efficient extraction technique for determination of four bioactive flavonoids from Pollen Typhae using a combination of ultrasound-assisted extraction and natural deep eutectic solvents (NADESs) was developed. A series of DESs containing various hydrogen bond acceptors combined with different hydrogen bond donors were synthesized and screened for high extraction efficiencies based on the flavonoids extraction yields. The extraction conditions including composition of DES, water content in DES, liquid-solid ratio, and extraction time were statistically optimized by single-factor experiment. As a result, DES composed of choline chloride and 1,2-propanediol (ChPri) at 1:4 M ratio, 30% of aqueous solution, 50:1 mg mL-1 for solid-liquid ratio, and 35 min for extraction time were selected as the most effective process for extraction of flavonoids in Pollen Typhae. Under the optimal conditions, the target compounds recoveries were in the range of 86.87%-98.89%. Meanwhile, DESs showed greater extraction efficiency for extraction of quercetin, naringenin, kaempferol and iso...Continue Reading

Citations

Aug 23, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Farid ChematAnne-Sylvie Fabiano Tixier
Aug 23, 2019·Journal of the Science of Food and Agriculture·Mariana Ruesgas-RamónErwann Durand
Sep 22, 2020·Critical Reviews in Analytical Chemistry·Sing Chuong ChuoAbdullah Alarifi
Dec 17, 2020·Comprehensive Reviews in Food Science and Food Safety·Leonardo M de Souza MesquitaVeridiana V de Rosso
Mar 20, 2021·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Reza AkramipourMohammad Reza Golpayegani
May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jeniffer Torres-VegaEdgar Pastene-Navarrete
Jun 26, 2021·Frontiers in Microbiology·Cíntia M Dos SantosVeridiana V de Rosso

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