Green and Mechanochemical One-Pot Multicomponent Synthesis of Bioactive 2-amino-4H -benzo[b ]pyrans via Highly Efficient Amine-Functionalized SiO2 @Fe3 O4 Nanoparticles

ACS Omega
Preeti SinghSatish K Awasthi

Abstract

An ecofriendly, magnetically retrievable amine-functionalized SiO2@Fe3O4 catalyst was successfully synthesized and affirmed by several physicochemical characterization tools, such as scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier-transform infrared spectroscopy (FT-IR), vibrating sample magnetometry (VSM), energy-dispersive X-ray spectroscopy (EDX), and powder X-ray diffraction. Thereafter, the catalytic performance of this environmentally benign NH2@SiO2@Fe3O4 catalyst was investigated in the one-pot multicomponent synthesis of 2-amino-4H-benzo[b]pyran derivatives. The reaction was simply achieved by grinding of various substituted aromatic aldehydes, dimedone, and malononitrile at room temperature under solvent and waste-free conditions with excellent yields and high purity. Moreover, the developed catalyst not only possesses immense potential to accelerate the synthesis of bioactive pyran derivatives but also exhibits several remarkable attributes like broad functional group tolerance, durability, improved yield, reusability, and recyclability. Besides, various other fascinating advantages of this protocol are milder reaction conditions, cost effectiveness, short reaction time, and simple...Continue Reading

References

Jun 22, 2000·Proceedings of the National Academy of Sciences of the United States of America·J L WangZ Huang
Feb 9, 2006·Chemical Communications : Chem Comm·Masih Darbandi, Thomas Nann
Feb 17, 2006·Journal of Medicinal Chemistry·Andrew V StachulskiJean-François Rossignol
Sep 6, 2011·Chemical Society Reviews·Stuart L JamesDaniel C Waddell
Sep 21, 2013·Future Medicinal Chemistry·Shivaputra A PatilDuane D Miller
Sep 3, 2014·Chemistry : a European Journal·Vanessa G SantosSimon J Garden
Jan 26, 2018·European Journal of Medicinal Chemistry·Neesha YadavSatish K Awasthi

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BETA
X-ray
Infrared Spectroscopy
scanning electron microscopy

Software Mentioned

winGX
olex

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