Green Fabrication of Amphiphilic Quaternized β-Chitin Derivatives with Excellent Biocompatibility and Antibacterial Activities for Wound Healing

Advanced Materials
Huan XuJie Cai

Abstract

Bacterial infection has always been a great threat to public health, and new antimicrobials to combat it are urgently needed. Here, a series of quaternized β-chitin derivatives is prepared simply and homogeneously in an aqueous KOH/urea solution, which is a high-efficiency, energy-saving, and "green" route for the modification of chitin. The mild reaction conditions keep the acetamido groups of β-chitin intact and introduce quaternary ammonium groups on the primary hydroxyl at the C-6 position of the chitin backbone, allowing the quaternized β-chitin derivatives (QCs) to easily form micelles. These QCs are found to exhibit excellent antimicrobial activities against Escherichia coli, Staphylococcus aureus, Candida albicans, and Rhizopus oryzae with minimum inhibitory concentrations (MICs) of 8, 12, 60, and 40 µg mL-1 , respectively. As a specific highlight, their inherent outstanding biocompatibility and significant accelerating effects on the healing of uninfected, E. coli-infected, and S. aureus-infected wounds imply that these novel polysaccharide-based materials can be used as dressings for clinical skin regeneration, particularly for infected wounds.

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Citations

Sep 12, 2018·Advanced Materials·Can Yang ZhangZhenjia Wang
Apr 22, 2020·Journal of Biomedical Materials Research. Part a·Lilong GaoHailin Cong
Jun 11, 2019·Journal of Biomaterials Science. Polymer Edition·Tianyu LanXiangchun Shen
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Oct 6, 2020·Advanced Healthcare Materials·Xuecheng HeXueji Zhang
Apr 14, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Yi-Fan ShenJing-Feng Li
Jan 19, 2021·Macromolecular Bioscience·Huan XuXiaofang Gao
Feb 6, 2021·Carbohydrate Polymers·Pengpeng DengJinping Zhou
Mar 14, 2021·Carbohydrate Polymers·Pengpeng DengJinping Zhou
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Apr 16, 2021·ACS Nano·Yu WangYuanjin Zhao
Apr 26, 2021·International Journal of Biological Macromolecules·Yan MengXiaojuan Xu
Jun 5, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Tian XiaYanfeng Wang
Jun 13, 2021·Macromolecular Bioscience·Xiaohan SuJun Wu
Jul 3, 2021·Membranes·Abayomi Babatunde AlayandeEuntae Yang
Jul 7, 2021·ACS Applied Materials & Interfaces·Fazli WahidCheng Zhong

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