Green fluorescent diamidines as diagnostic probes for trypanosomes

Antimicrobial Agents and Chemotherapy
Federica GiordaniMichael P Barrett

Abstract

Light-emitting diode (LED) fluorescence microscopy offers potential benefits in the diagnosis of human African trypanosomiasis and in other aspects of diseases management, such as detection of drug-resistant strains. To advance such approaches, reliable and specific fluorescent markers to stain parasites in human fluids are needed. Here we describe a series of novel green fluorescent diamidines and their suitability as probes with which to stain trypanosomes.

References

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Citations

Jun 9, 2015·Bioorganic & Medicinal Chemistry Letters·Ananya PaulW David Wilson
Jun 29, 2015·Bioorganic & Medicinal Chemistry·Michael L BergerTien L Huang
Dec 31, 2019·Chemistry : a European Journal·Abdelbasset A FarahatW David Wilson
Jun 11, 2020·Diagnostics·Emma Michelle Taylor
Mar 15, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ananya PaulW David Wilson
Oct 26, 2018·Journal of the American Chemical Society·Pu GuoW David Wilson

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Methods Mentioned

BETA
fluorescence microscopy
Fluorescence

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