Green synthesis of bacterial gold nanoparticles conjugated to resveratrol as delivery vehicles

Colloids and Surfaces. B, Biointerfaces
C Ganesh KumarSuman Kumar Mamidyala


Bio-directed synthesis of metal nanoparticles is gaining importance in view of their biocompatibility, low toxicity and eco-friendly characteristics. The present study describes the application of resveratrol conjugated gold nanoparticles as effective delivery vehicles. The green chemistry approach was used for the synthesis of gold nanoparticles by using the culture supernatant of Delftia sp. strain KCM-006. The synthesized gold nanoparticles were mono-dispersed, spherical in shape with an average size of 11.3 nm. They were found to be photoluminescent and crystalline in nature with a zeta potential of -25 mV, indicating their high stability. Resveratrol, an anticancer drug, was conjugated to these gold nanoparticles (RSV-AuNP). The cell viability and immunocytochemistry analysis with human lung cancer cell line (A549) demonstrated that RSV-AuNPs were 65% more effective as drug when compared to resveratrol alone. In vitro observations on the drug release from these nanoparticles exhibited pH dependency; the release was significant (95%) under acidic conditions (pH 5.2) when compared to physiological conditions (pH 7.4).


Jan 30, 2002·Antioxidants & Redox Signaling· Bhat KPLJ M Pezzuto
Jan 6, 2004·Nature Biotechnology·Paul Alivisatos
Jan 17, 2004·International Journal of Pharmaceutics·J Allen ZhangImran Ahmad
May 4, 2004·Journal of Nanobiotechnology·OV Salata
Aug 11, 2006·The Journal of Physical Chemistry. B·J KimlingA Plech
Apr 10, 2007·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Ferenc BillesErno Tyihák
Mar 18, 2009·Proceedings of the National Academy of Sciences of the United States of America·Sirisha PeddibhotlaJeffrey M Rosen
Apr 20, 2010·Angewandte Chemie·David A GiljohannChad A Mirkin
Jun 18, 2010·European Journal of Medicinal Chemistry·Ahmed KamalShasi V Kalivendi
Aug 18, 2010·Current Molecular Medicine·R SeigneuricC Garrido
Mar 1, 2011·Colloids and Surfaces. B, Biointerfaces·C Ganesh Kumar, Suman Kumar Mamidyala
Feb 5, 2013·Nature Chemical Biology·Chad W JohnstonNathan A Magarvey
Oct 12, 2013·Cancer Treatment and Research·Adriana BorrielloFulvio Della Ragione


Nov 2, 2015·Advances in Colloid and Interface Science·Justyna ŁuczakAdriana Zaleska-Medynska
Sep 5, 2015·Colloids and Surfaces. B, Biointerfaces·Gheorghe TomoaiaMaria Tomoaia-Cotisel
Oct 20, 2015·Materials Science & Engineering. C, Materials for Biological Applications·Sohyun ParkYoumie Park
Aug 1, 2015·Nanomedicine·Sandeep KumarDeepti Pandita
Oct 6, 2016·Journal of Photochemistry and Photobiology. B, Biology·Seon Yeong ChaeGeuntae Park
Dec 30, 2017·Antioxidants·Sharoon GriffinClaus Jacob
Mar 10, 2016·Nanotechnology·Wenjing WangBai Yang
Oct 19, 2019·IET Nanobiotechnology·Senthil Kumar ChinnaiyanMadhan Balaraman
Dec 15, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Dominique Vervandier-Fasseur, Norbert Latruffe
Feb 11, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Andrea RónaváriMonika Kiricsi
Dec 17, 2020·International Journal of Nanomedicine·Sundus Jabeen Amina, Bin Guo

Related Concepts

Cell Line, Tumor
Cell Proliferation
Metal Nanoparticles
Antineoplastic Agents
Cell Survival

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Pediculosis pubis

Pediculosis pubis is a disease caused by a parasitic insect known as Pthirus pubis, which infests human pubic hair, as well as other areas with hair including eye lashes. Here is the latest research.

Rh Isoimmunization

Rh isoimmunization is a potentially preventable condition that occasionally is associated with significant perinatal morbidity or mortality. Discover the latest research on Rh Isoimmunization here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells. It also follows CRISPR-Cas9 approaches to generating genetic mutants as a means of understanding the effect of genetics on phenotype.

Enzyme Evolution

This feed focuses on molecular models of enzyme evolution and new approaches (such as adaptive laboratory evolution) to metabolic engineering of microorganisms. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Pharmacology of Proteinopathies

This feed focuses on the pharmacology of proteinopathies - diseases in which proteins abnormally aggregate (i.e. Alzheimer’s, Parkinson’s, etc.). Discover the latest research in this field with this feed.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.