Green synthesis of bacterial gold nanoparticles conjugated to resveratrol as delivery vehicles

Colloids and Surfaces. B, Biointerfaces
C Ganesh KumarSuman Kumar Mamidyala

Abstract

Bio-directed synthesis of metal nanoparticles is gaining importance in view of their biocompatibility, low toxicity and eco-friendly characteristics. The present study describes the application of resveratrol conjugated gold nanoparticles as effective delivery vehicles. The green chemistry approach was used for the synthesis of gold nanoparticles by using the culture supernatant of Delftia sp. strain KCM-006. The synthesized gold nanoparticles were mono-dispersed, spherical in shape with an average size of 11.3 nm. They were found to be photoluminescent and crystalline in nature with a zeta potential of -25 mV, indicating their high stability. Resveratrol, an anticancer drug, was conjugated to these gold nanoparticles (RSV-AuNP). The cell viability and immunocytochemistry analysis with human lung cancer cell line (A549) demonstrated that RSV-AuNPs were 65% more effective as drug when compared to resveratrol alone. In vitro observations on the drug release from these nanoparticles exhibited pH dependency; the release was significant (95%) under acidic conditions (pH 5.2) when compared to physiological conditions (pH 7.4).

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Citations

Nov 2, 2015·Advances in Colloid and Interface Science·Justyna ŁuczakAdriana Zaleska-Medynska
Sep 5, 2015·Colloids and Surfaces. B, Biointerfaces·Gheorghe TomoaiaMaria Tomoaia-Cotisel
Oct 20, 2015·Materials Science & Engineering. C, Materials for Biological Applications·Sohyun ParkYoumie Park
Aug 1, 2015·Nanomedicine·Sandeep KumarDeepti Pandita
Oct 6, 2016·Journal of Photochemistry and Photobiology. B, Biology·Seon Yeong ChaeGeuntae Park
Dec 30, 2017·Antioxidants·Sharoon GriffinClaus Jacob
Mar 10, 2016·Nanotechnology·Wenjing WangBai Yang
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Feb 11, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Andrea RónaváriMonika Kiricsi
Dec 17, 2020·International Journal of Nanomedicine·Sundus Jabeen Amina, Bin Guo

Related Concepts

resveratrol-3-sulfate
Gold
Stilbenes
Delftia
Cell Line, Tumor
Cell Proliferation
Metal Nanoparticles
Antineoplastic Agents
Cell Survival
Metals

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