Green Tea Catechin, EGCG, Suppresses PCB 102-Induced Proliferation in Estrogen-Sensitive Breast Cancer Cells

International Journal of Breast Cancer
Kimberly Mantzke Baker, Angela C Bauer

Abstract

The persistence of polychlorinated biphenyls (PCBs) in the environment is of considerable concern since they accumulate in human breast tissue and may stimulate the growth of estrogen-sensitive tumors. Studies have shown that EGCG from green tea can modify estrogenic activity and thus may act as a cancer chemopreventive agent. In the present study, we evaluated the individual and combined effects of PCB 102 and EGCG on cell proliferation using an estrogen-sensitive breast cancer cell line MCF-7/BOS. PCB 102 (1-10 μM) increased cell proliferation in a dose-dependent manner. Furthermore, the proliferative effects of PCB 102 were mediated by ERα and could be abrogated by the selective ERα antagonist MPP. EGCG (10-50 μM) caused a dose-dependent inhibition of PCB 102-induced cell proliferation, with nearly complete inhibition at 25 μM EGCG. The antiproliferative action of EGCG was mediated by ERβ and could be blocked by the ERβ-specific inhibitor PHTPP. In conclusion, EGCG suppressed the proliferation-stimulating activity of the environmental estrogen PCB 102 which may be helpful in the chemoprevention of breast cancer.

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Oct 3, 2019·Scientific Reports·Cindy MendesJacinta Serpa
Aug 10, 2017·BioMed Research International·Andreia GranjaSalette Reis
Apr 24, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Sarmistha Mitra, Raju Dash
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Apr 28, 2020·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Rama Rao MallaVenkata Ramesh Dasari

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Methods Mentioned

BETA
PCB

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