Green tea catechins prevent low-density lipoprotein oxidation via their accumulation in low-density lipoprotein particles in humans

Nutrition Research
Norie Suzuki-SugiharaKazuo Kondo

Abstract

Green tea is rich in polyphenols, including catechins which have antioxidant activities and are considered to have beneficial effects on cardiovascular health. In the present study, we investigated the effects of green tea catechins on low-density lipoprotein (LDL) oxidation in vitro and in human studies to test the hypothesis that catechins are incorporated into LDL particles and exert antioxidant properties. In a randomized, placebo-controlled, double-blind, crossover trial, 19 healthy men ingested green tea extract (GTE) in the form of capsules at a dose of 1 g total catechin, of which most (>99%) was the gallated type. At 1 hour after ingestion, marked increases of the plasma concentrations of (-)-epigallocatechin gallate and (-)-epicatechin gallate were observed. Accordingly, the plasma total antioxidant capacity was increased, and the LDL oxidizability was significantly reduced by the ingestion of GTE. We found that gallated catechins were incorporated into LDL particles in nonconjugated forms after the incubation of GTE with plasma in vitro. Moreover, the catechin-incorporated LDL was highly resistant to radical-induced oxidation in vitro. An additional human study with 5 healthy women confirmed that GTE intake sufficien...Continue Reading

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Citations

Oct 25, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Chih-Wei ChenShu-Hua Chiang
Jan 31, 2017·Nature Reviews. Endocrinology·Paola M Hunter, Robert A Hegele
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Jan 18, 2019·Journal of Agricultural and Food Chemistry·Lujuan XingYoshinori Mine

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