Green tea extract attenuates hepatic steatosis by decreasing adipose lipogenesis and enhancing hepatic antioxidant defenses in ob/ob mice

The Journal of Nutritional Biochemistry
Hea Jin ParkRichard S Bruno

Abstract

Excess hepatic lipid accumulation and oxidative stress contribute to nonalcoholic fatty liver disease (NAFLD). Thus, we hypothesized that the hypolipidemic and antioxidant activities of green tea extract (GTE) would attenuate events leading to NAFLD. Obese mice (ob/ob; 5 weeks old, n=38) and their lean littermates (n=12) were fed 0%, 0.5% or 1% GTE for 6 weeks. Then, hepatic steatosis, oxidative stress and inflammatory markers were measured. Obese mice, compared to lean controls, had greater hepatic lipids and serum alanine aminotransferase (ALT). GTE at 1% lowered (P<.05) hepatic lipids and ALT in obese mice. The GTE-mediated attenuation in hepatic steatosis was accompanied by decreased mRNA expression of adipose sterol regulatory element-binding protein-1c, fatty acid synthase, stearoyl CoA desaturase-1, and hormone-sensitive lipase and decreased serum nonesterified fatty acid concentrations. Immunohistochemical data indicated that steatotic livers from obese mice had extensive accumulation of tumor necrosis factor-α (TNF-α), whereas GTE at 1% decreased hepatic TNF-α protein and inhibited adipose TNF-α mRNA expression. Hepatic total glutathione, malondialdehyde and Mn- and Cu/Zn-superoxide dismutase activities in obese mice f...Continue Reading

References

Aug 1, 1985·Archives of Biochemistry and Biophysics·J Blum, I Fridovich
Jan 1, 1983·Annual Review of Biochemistry·A Meister, M E Anderson
Mar 18, 1995·BMJ : British Medical Journal·K Imai, K Nakachi
Jan 1, 1996·Free Radical Biology & Medicine·J A EscobarE A Lissi
Jun 22, 2000·Archives of Biochemistry and Biophysics·S YangA M Diehl
Apr 19, 2002·The New England Journal of Medicine·Paul Angulo
Jul 18, 2002·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·C Ayyad, T Andersen
Jan 24, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Zhiping LiAnna Mae Diehl
Jul 23, 2003·The Journal of Nutritional Biochemistry·Daniel G RaederstorffPeter Weber
Aug 7, 2003·Biochemical and Biophysical Research Communications·Jude A ObenAnna Mae Diehl
Feb 19, 2005·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Ryan N FioriniKenneth D Chavin
Oct 4, 2005·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Anna Mae Diehl
Mar 2, 2006·Journal of Agricultural and Food Chemistry·Yoko ShishikuraBrent S Murray
Sep 14, 2006·JAMA : the Journal of the American Medical Association·Shinichi KuriyamaIchiro Tsuji
Feb 14, 2007·The Journal of Nutritional Biochemistry·Sung I Koo, Sang K Noh
Oct 30, 2007·Molecular Pharmaceutics·Joshua D LambertChung S Yang
Dec 18, 2007·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Hye-Kyung Na, Young-Joon Surh
Mar 29, 2008·European Journal of Pharmacology·Jing ZhaoYan Li
Jul 9, 2008·Scandinavian Journal of Clinical and Laboratory Investigation·K S DasD M Vasudevan
Aug 12, 2008·Journal of the American College of Nutrition·Claudia P M S de OliveiraMarcelo G de Oliveira
Aug 12, 2008·Current Medicinal Chemistry·Pon Velayutham Anandh Babu, Dongmin Liu
Aug 30, 2008·Journal of Gastroenterology and Hepatology·Claire Z Larter, Matthew M Yeh
Dec 4, 2008·Phytotherapy Research : PTR·Hye-Jin KimMyung-Sook Choi
Feb 7, 2009·Diabetes & Metabolism·C Postic, J Girard
Feb 10, 2009·European Journal of Clinical Pharmacology·Gabriela MazzantiSabina Mastrangelo
May 12, 2009·Journal of Clinical Biochemistry and Nutrition·Kazuo NakamotoAkitane Mori
Nov 4, 2009·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Joshua D LambertChung S Yang

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Citations

Apr 6, 2013·Hepatobiliary & Pancreatic Diseases International : HBPD INT·Jia XiaoGeorge L Tipoe
Aug 15, 2012·Journal of Nutrition in Gerontology and Geriatrics·Ryan T Hurt, Ted Wilson
Jan 22, 2011·Journal of Biomedicine & Biotechnology·Sunil K Panchal, Lindsay Brown
Jul 31, 2014·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Curtis C HugheyLouise Lantier
Oct 1, 2013·Journal of Natural Medicines·Lorisa S TeixeiraEmerson S Lima
Oct 3, 2014·The British Journal of Nutrition·Jayagopalan VeenaSwaminathan Subramaniam
Jan 10, 2012·Nutrition Reviews·Christopher Masterjohn, Richard S Bruno
Jun 12, 2013·Canadian Journal of Physiology and Pharmacology·Carani Venkatraman Anuradha
Dec 10, 2013·The Journal of Nutritional Biochemistry·Shu WangChwan-Li Shen
Jan 1, 2014·The Journal of Nutritional Biochemistry·Bradley J NewsomeBernhard Hennig
Aug 10, 2013·Metabolism: Clinical and Experimental·Virginia L MalloyNorman Orentreich
Jan 26, 2016·Reproductive Biomedicine Online·Rocío Nuñez-CalongeJesús Tresguerres
Sep 1, 2015·Molecular Nutrition & Food Research·Yinghua YuXu-Feng Huang
Mar 10, 2016·International Journal of Preventive Medicine·Ali PezeshkiFatemeh Karami
Jan 5, 2011·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Sudathip Sae-tanJoshua D Lambert
Oct 18, 2011·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·M Pilar ValdecantosJ Alfredo Martínez
Sep 4, 2012·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Satyakumar VidyashankarPralhad Sadashiv Patki
Jan 26, 2013·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Satyakumar VidyashankarPralhad Sadashiv Patki
Sep 3, 2013·Free Radical Biology & Medicine·Gaetano ServiddioGianluigi Vendemiale
Apr 22, 2015·Critical Reviews in Food Science and Nutrition·Bregje Van De WierGuido R M M Haenen
Oct 2, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Yihong LuLaura K Schnackenberg
Jul 31, 2014·European Journal of Clinical Nutrition·J HuangX Wan
Jul 14, 2011·International Journal of Obesity : Journal of the International Association for the Study of Obesity·M FriedrichS Klaus

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