Green Tea Liquid Consumption Alters the Human Intestinal and Oral Microbiome

Molecular Nutrition & Food Research
Xiaojie YuanZhongjun Shao

Abstract

GTPs (green tea polyphenols) exert anti-CRC (colorectal cancer) activity. The intestinal microbiota and intestinal colonization by bacteria of oral origin has been implicated in colorectal carcinogenesis. GT modulates the composition of mouse gut microbiota harmonious with anticancer activity. Therefore, the effect of green tea liquid (GTL) consumption on the gut and oral microbiome is investigated in healthy volunteers (n = 12). 16S sequencing and phylogenetic investigation of communities by reconstruction of unobserved states (PICRUSt) analysis of both fecal and saliva samples (collected before intervention, after 2 weeks of GTL (400 mL per day) and after a washout period of one week) in healthy volunteers show changes in microbial diversity and core microbiota and difference in clear classification (partial least squares-discriminant analysis [PLS-DA]). An irreversible, increased FIR:BAC (Firmicutes to Bacteroidetes ratio), elevated SCFA producing genera, and reduction of bacterial LPS synthesis in feces are discovered in response to GTL. GTL alters the salivary microbiota and reduces the functional pathways abundance relevance to carcinogenesis. Similar bacterial networks in fecal and salivary microbiota datasets comprising...Continue Reading

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Citations

Mar 15, 2019·Critical Reviews in Food Science and Nutrition·Xiao-Yu XuHua-Bin Li
May 19, 2019·Clinical Pharmacology and Therapeutics·Caroline Birer, Erik S Wright
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Methods Mentioned

BETA
16S
PCR
PCA
16S sequencing

Software Mentioned

Phylogenetic Investigation of Communities by Reconstruction of...
SIMPER
UCHIME
SPSS
DA
GraphPad Prism
PAST
UPARSE
LEfSe
QIIME

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