Green tea phenol extracts reduce UVB-induced DNA damage in human cells via interleukin-12

Photochemistry and Photobiology
Agatha SchwarzThomas Schwarz

Abstract

Green tea chemoprevention has been a focus of recent research, as a polyphenolic fraction from green tea (GTP) has been suggested to prevent UV radiation-induced skin cancer. Recently, it was demonstrated that GTP reduced the risk for skin cancer in a murine photocarcinogenesis model. This was accompanied by a reduction in UV-induced DNA damage. These effects appeared to be mediated via interleukin (IL)-12, which was previously shown to induce DNA repair. Therefore, we studied whether GTP induction of IL-12 and DNA repair could also be observed in human cells. KB cells and normal human keratinocytes were exposed to GTP 5 h before and after UVB. UVB-induced apoptosis was reduced in UVB-exposed cells treated with GTP. GTP induced the secretion of IL-12 in keratinocytes. The reduction in UV-induced cell death by GTP was almost completely reversed upon addition of an anti-IL-12-antibody, indicating that the reduction of UV-induced cell death by GTP is mediated via IL-12. The ability of IL-12 to reduce DNA damage and sunburn cells was confirmed in "human living skin equivalent" models. Hence the previously reported UV-protective effects of GTP appear to be mediated in human cells via IL-12, most likely through induction of DNA repair.

References

May 1, 1993·Photochemistry and Photobiology·D Nelson, R J Gay
Oct 14, 1993·The New England Journal of Medicine·S C ThompsonR Marks
Jul 7, 1993·Journal of the National Cancer Institute·C S Yang, Z Y Wang
Sep 1, 1996·Scientific American·P Greenwald
Jun 1, 1996·The Journal of Investigative Dermatology·A SchwarzT Schwarz
Nov 14, 1997·Proceedings of the National Academy of Sciences of the United States of America·M S EllerB A Gilchrest
Jan 1, 1997·Advances in Experimental Medicine and Biology·S K Clinton
Aug 14, 1998·Journal of the American Academy of Dermatology·J J DiGiovanna
Jul 8, 1999·Proceedings of the National Academy of Sciences of the United States of America·D KulmsT Schwarz
Feb 8, 2000·Proceedings of the National Academy of Sciences of the United States of America·H StegeJ Krutmann
Mar 10, 2000·Journal of Epidemiology·A D WoodheadM Tanaka
Feb 24, 2001·Journal of the American Academy of Dermatology·C A ElmetsH Mukhtar
Jan 10, 2002·Nature Cell Biology·Agatha SchwarzThomas Schwarz
Feb 4, 2003·Nature Reviews. Immunology·Giorgio Trinchieri
Aug 5, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jin Ho ChungHee Chul Eun
Mar 5, 2004·Proceedings of the National Academy of Sciences of the United States of America·David A GoukassianBarbara A Gilchrest
Aug 12, 2004·The Journal of Investigative Dermatology·Nihal Ahmad, Hasan Mukhtar
Dec 1, 2004·The Journal of Biological Chemistry·Markus BöhmAgatha Schwarz
Jan 20, 2005·The Journal of Experimental Medicine·Agatha SchwarzThomas Schwarz
Aug 24, 2005·Archives of Pharmacal Research·So-Young KimKyoung-Chan Park
Feb 24, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Agatha SchwarzThomas Schwarz
Mar 17, 2006·Cancer Research·Akira MaedaAgatha Schwarz
Apr 13, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Syed M MeeranSantosh K Katiyar
Aug 1, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Simin AradBarbara A Gilchrest
Aug 3, 2006·Experimental Dermatology·Farrukh Afaq, Hasan Mukhtar
Apr 24, 2007·Cancer Letters·Jeremy James Johnson, Hasan Mukhtar
Jul 7, 2007·Seminars in Cancer Biology·Deeba N SyedHasan Mukhtar
Jul 28, 2007·Life Sciences·Naghma Khan, Hasan Mukhtar

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Citations

Oct 24, 2009·European Journal of Nutrition·Nina KagerSiegfried Knasmüller
Nov 10, 2009·Archives of Dermatological Research·Joi A Nichols, Santosh K Katiyar
Nov 26, 2010·Archives of Biochemistry and Biophysics·Santosh K Katiyar
Dec 15, 2010·Archives of Biochemistry and Biophysics·Farrukh Afaq
Jan 19, 2011·Immunology and Cell Biology·Heather M McGeeGregory M Woods
May 21, 2011·Journal of Toxicology and Environmental Health. Part a·Federico S WeillDaniel H Gonzalez Maglio
Apr 30, 2013·PloS One·Seoung Woo ShinDeokhoon Park
Mar 19, 2014·Journal of Dermatological Science·Hannah LiuAnthony A Gaspari
Feb 19, 2016·British Journal of Cancer·Emily M BowenElizabeth K Cahoon
Apr 29, 2014·Expert Opinion on Biological Therapy·Eggert Stockfleth, Thomas Meyer
Feb 3, 2012·The Journal of Investigative Dermatology·Christian JantschitschAgatha Schwarz
Sep 2, 2010·Clinical and Experimental Dermatology·Y WuY-H Li
May 25, 2012·The Journal of Investigative Dermatology·Judith G M BergboerJoost Schalkwijk
May 9, 2014·The Journal of Investigative Dermatology·Craig A ElmetsMohammad Athar
Nov 16, 2012·The Journal of Investigative Dermatology·Milène Kennedy CrispinJames G Krueger
Nov 29, 2012·The Journal of Investigative Dermatology·Hui Xu, Craig A Elmets
Feb 5, 2014·Dermato-endocrinology·Wannit Tongkao-OnRebecca S Mason
Apr 10, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Gabriela Adriana FilipSimona Clichici
Jun 11, 2014·Critical Reviews in Food Science and Nutrition·Masood Sadiq ButtAmbreen Naz
Jan 8, 2017·Photochemistry and Photobiology·Mary K Montes de OcaFarrukh Afaq
Oct 1, 2013·Multiple Sclerosis : Clinical and Laboratory Research·Dimitry N Krementsov, Cory Teuscher
Apr 26, 2014·Lupus·M Barbhaiya, K H Costenbader
Jul 27, 2017·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·J L FuentesE E Stashenko
May 12, 2010·Nature Reviews. Urology·Jens Bedke, Arnulf Stenzl
Jul 14, 2010·Current Oncology Reports·Lilit Garibyan, David E Fisher
Aug 20, 2011·Nature Reviews. Immunology·Prue H HartJohn J Finlay-Jones
Mar 5, 2009·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Anthony AndradyUNKNOWN United Nations Environment Programme, Environmental Effects Assessment Panel
Jul 4, 2008·Current Opinion in Allergy and Clinical Immunology·Andrea Cavani
May 17, 2011·Cellular and Molecular Life Sciences : CMLS·Jamie J Bernard, Richard L Gallo
Jun 30, 2011·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Mary Norval, Gregory M Woods
Sep 5, 2012·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Sarah FeltonLesley E Rhodes
Apr 29, 2014·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Scott N Byrne
Jun 27, 2014·Food & Function·Elisabet Fernández-García
Jan 22, 2011·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·M NorvalJ C van der Leun
Oct 18, 2011·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Naomi M ScottPrue H Hart
Jun 20, 2019·Nature Reviews. Immunology·Jamie J BernardJean Krutmann
Jan 11, 2012·Experimental Dermatology·Johannes RegensburgerWolfgang Bäumler
Feb 26, 2016·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·N A SchweintzgerP Wolf

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