Green tea polyphenol (epigallocatechin-3-gallate) improves gut dysbiosis and serum bile acids dysregulation in high-fat diet-fed mice

Journal of Clinical Biochemistry and Nutrition
Chihiro UshirodaYoshito Itoh

Abstract

Gut microbiota have profound effects on bile acid metabolism by promoting deconjugation, dehydrogenation, and dehydroxylation of primary bile acids in the distal small intestine and colon. High-fat diet-induced dysbiosis of gut microbiota and bile acid dysregulation may be involved in the pathology of steatosis in patients with non-alcoholic fatty liver disease. Epigallocatechin-3-gallate (EGCG), the most abundant polyphenolic catechin in green tea, has been widely investigated for its inhibitory or preventive effects against fatty liver. The aim of the present study was to investigate the effects of EGCG on the abundance of gut microbiota and the composition of serum bile acids in high-fat diet-fed mice and determine the specific bacterial genera that can improve the serum bile acid dysregulation associated with EGCG anti-hepatic steatosis action. Male C57BL/6N mice were fed with the control diet, high-fat diet, or high-fat diet + EGCG at a concentration of 0.32% for 8 weeks. EGCG significantly inhibited the increases in weight, the area of fatty lesions, and the triglyceride content in the liver induced by the high-fat diet. Principal coordinate analysis revealed significant differences in microbial structure among the groups...Continue Reading

References

May 12, 2004·Regulatory Toxicology and Pharmacology : RTP·K SchneiderM Hassauer
Oct 26, 2005·Journal of Pharmaceutical and Biomedical Analysis·Masayuki AndoJunichi Goto
Aug 10, 2006·Proceedings of the National Academy of Sciences of the United States of America·Marc-Emmanuel DumasJeremy K Nicholson
Jul 2, 2009·The British Journal of Nutrition·Megumi MatsumotoTakaji Yajima
Nov 13, 2009·Journal of Gastroenterology·Juntaro MatsuzakiToshifumi Hibi
Apr 13, 2010·Nature Methods·J Gregory CaporasoRob Knight
Aug 17, 2010·Bioinformatics·Robert C Edgar
Oct 26, 2012·Journal of Gastroenterology and Hepatology·Toshihiro NishizawaToshifumi Hibi
Oct 24, 2013·Current Gastroenterology Reports·Mark PimentelChristopher Chang
Nov 28, 2013·Journal of Gastroenterology and Hepatology·Etsuko HashimotoKatsutoshi Tokushige
Aug 1, 2014·Journal of Nutritional Science and Vitaminology·Tomonori UnnoShiho Mitsuhashi
Apr 18, 2015·Current Drug Targets·Marialena Mouzaki, Robert Bandsma
Jul 15, 2015·Nutrition Research Reviews·Kristin A VerbekeKieran M Tuohy
Sep 22, 2015·Journal of Clinical Biochemistry and Nutrition·Won-Young SongMasashi Mizuno
Jan 16, 2016·American Journal of Physiology. Gastrointestinal and Liver Physiology·Yasuki HigashimuraToshikazu Yoshikawa
Jul 1, 2016·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Juan P ArabMichael Trauner
Sep 13, 2016·Molecular Metabolism·Stavros BashiardesEran Elinav
Oct 12, 2017·Bioscience, Biotechnology, and Biochemistry·Ryo InoueTakamitsu Tsukahara
Feb 15, 2018·Frontiers in Microbiology·Emma T SaltzmanLuis Vitetta
Mar 25, 2018·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Cyrielle CaussyUNKNOWN Genetics of NAFLD in Twins Consortium
Apr 25, 2018·Inflammatory Bowel Diseases·Masashi MurakamiYasushi Matsuzaki
Jun 9, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Lili ShengYu-Jui Yvonne Wan
Jun 21, 2018·Frontiers in Microbiology·Glynn MartinJonathan R Swann
Jul 20, 2018·Nature Communications·Jane M NatividadHarry Sokol
Aug 9, 2018·Journal of Clinical Biochemistry and Nutrition·Yuji NaitoTomohisa Takagi

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Citations

Jun 7, 2020·International Journal of Molecular Sciences·Levi W EvansBradley S Ferguson
Jun 12, 2020·Chinese Journal of Integrative Medicine·Hong-Shan Li, Yi-Yang Hu
Sep 10, 2020·International Journal of Molecular Sciences·Susanne NaumannUte Schweiggert-Weisz
Nov 13, 2020·World Journal of Gastroenterology : WJG·Jian-Hong DingJing-Yu Xu
Feb 12, 2021·International Journal of Environmental Research and Public Health·Małgorzata MoszakPaweł Bogdański
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sergio Pérez-BurilloJosé Ángel Rufián-Henares
Jul 17, 2021·Frontiers in Nutrition·Maria Carolina Rodríguez-DazaDenis Roy
Feb 12, 2020·Gastroenterology·Judith Aron-WisnewskyKarine Clément
Oct 5, 2021·Critical Reviews in Food Science and Nutrition·Ramkumar SamynathanJosé M Lorenzo

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Datasets Mentioned

BETA
PRJDB7523

Methods Mentioned

BETA
nucleic acid extraction
PCR
Illumina sequencing

Software Mentioned

JMP
QIIME
PERMANOVA
R “ phyloseq ”
in
USEARCH
All
Graph Pad Prism
- One

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