Green tea polyphenols decreases uric acid level through xanthine oxidase and renal urate transporters in hyperuricemic mice

Journal of Ethnopharmacology
Gang ChenChun-Hay Ko

Abstract

Green tea is a Chinese materia medica with the main functions of "inducing urination and quenching thirst". Green tea polyphenols (GTP) are generally acknowledged as the main active fraction with multiple pharmacological functions in green tea. However, the effect of GTP on hyperuricemia is not clear till now. The present study was carried out to investigate the effect of GTP on serum level of uric acid in potassium oxonate (PO)-induced hyperuricemic mice, and explore the underlying mechanisms from two aspects of production and excretion of uric acid. PO and GTP were intragastricly administered to mice for consecutive 7 days. Serum level of uric acid, and xanthine oxidase (XOD) activity in serum and liver were examined. Simultaneously, expression of XOD protein in liver was analyzed by Western blot assay. Expressions of urate transporters including urate-anion transporter (URAT) 1, organic anion transporter (OAT) 1 and 3 in kidney were analyzed by immunohistochemistry staining method. 300 and 600 mg/kg GTP significantly decreased serum level of uric acid of hyperuricemic mice in a dose-dependent manner (p<0.05 or p<0.01). Besides, 300 and 600 mg/kg GTP markedly reduced XOD activity in serum and liver of hyperuricemic mice (both...Continue Reading

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Citations

Jan 20, 2017·Cytotechnology·Shin-Ichi AdachiKazumi Yagasaki
Dec 28, 2017·Critical Reviews in Food Science and Nutrition·Arshad MehmoodAmjad Abbas Shah
Jan 30, 2019·Food & Function·Xiaoyun QianWenhua Ling
Jan 8, 2020·The Journal of Pharmacy and Pharmacology·Wen-Hao XuWei-Ke Su
Apr 30, 2020·Journal of Food Biochemistry·Arshad MehmoodMuhammad Nadeem
Aug 25, 2019·Nutrients·Stefanos RoumeliotisVassilios Liakopoulos
May 24, 2019·Nature Reviews. Rheumatology·Jie LuWen-Hua Wei
Nov 17, 2016·Evidence-based Complementary and Alternative Medicine : ECAM·Shijun HaoHaiyan Song
May 10, 2018·Frontiers in Physiology·Félix VargasJoaquín García-Estañ
Nov 8, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Shin-Ichi AdachiKazumi Yagasaki
Jul 25, 2021·International Journal of Environmental Research and Public Health·Joong Seob LeeHyo Geun Choi
Jul 20, 2020·Mini Reviews in Medicinal Chemistry·Dan WuFanrong Cao
Sep 2, 2021·Brazilian Journal of Biology = Revista Brasleira De Biologia·Leonardo Luiz BorgesEdemilson Cardoso da Conceição

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