Grey matter, an endophenotype for schizophrenia? A voxel-based morphometry study in siblings of patients with schizophrenia

Journal of Psychiatry & Neuroscience : JPN
Jorien van der VeldeAndré Aleman

Abstract

Grey matter, both volume and concentration, has been proposed as an endophenotype for schizophrenia given a number of reports of grey matter abnormalities in relatives of patients with schizophrenia. However, previous studies on grey matter abnormalities in relatives have produced inconsistent results. The aim of the present study was to examine grey matter differences between controls and siblings of patients with schizophrenia and to examine whether the age, genetic loading or subclinical psychotic symptoms of selected individuals could explain the previously reported inconsistencies. We compared the grey matter volume and grey matter concentration of healthy siblings of patients with schizophrenia and healthy controls matched for age, sex and education using voxel-based morphometry (VBM). Furthermore, we selected subsamples based on age (< 30 yr), genetic loading and subclinical psychotic symptoms to examine whether this would lead to different results. We included 89 siblings and 69 controls in our study. The results showed that siblings and controls did not differ significantly on grey matter volume or concentration. Furthermore, specifically selecting participants based on age, genetic loading or subclinical psychotic sym...Continue Reading

Citations

Mar 18, 2017·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Sandra Van der AuweraHans J Grabe
May 1, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Wenjing ZhangFabiano G Nery
Sep 28, 2018·Frontiers in Neuroscience·Guixian XiaoKai Wang
Jan 11, 2019·Translational Vision Science & Technology·Dong-Yi LanYi Shao

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