Grey matter volume in healthy and epileptic beagles using voxel-based morphometry - a pilot study

BMC Veterinary Research
Lisa FrankAndrea Tipold

Abstract

One of the most common chronic neurological disorders in dogs is idiopathic epilepsy (IE) diagnosed as epilepsy without structural changes in the brain. In the current study the hypothesis should be proven that subtle grey matter changes occur in epileptic dogs. Therefore, magnetic resonance (MR) images of one dog breed (Beagles) were used to obtain an approximately uniform brain shape. Local differences in grey matter volume (GMV) were compared between 5 healthy Beagles and 10 Beagles with spontaneously recurrent seizures (5 dogs with IE and 5 dogs with structural epilepsy (SE)), using voxel-based morphometry (VBM). T1W images of all dogs were prepared using Amira 6.3.0 for brain extraction, FSL 4.1.8 for registration and SPM12 for realignment. After creation of tissue probability maps of cerebrospinal fluid, grey and white matter from control images to segment all extracted brains, GM templates for each group were constructed to normalize brain images for parametric statistical analysis, which was achieved using SPM12. Epileptic Beagles (IE and SE Beagles) displayed statistically significant reduced GMV in olfactory bulb, cingulate gyrus, hippocampus and cortex, especially in temporal and occipital lobes. Beagles with IE show...Continue Reading

References

Jan 1, 1978·Annals of Neurology·M SalcmanS Gilman
Sep 1, 1985·Annals of Neurology·G NevanderB K Siesjö
Mar 1, 1983·Veterinary Pathology·D L Montgomery, A C Lee
Apr 13, 1996·The Veterinary Record·S J Hall, M E Wallace
Nov 19, 1997·Progress in Neurobiology·W Löscher
Jul 23, 1998·The Journal of Small Animal Practice·A JaggyH Graber
Jun 22, 2000·NeuroImage·J Ashburner, K J Friston
Aug 8, 2001·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·J Engel
May 31, 2003·Journal of Veterinary Internal Medicine·Edward E PattersonP Jane Armstrong
Sep 24, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·P Dwight TappMin-Ying Su
Jan 14, 2005·Journal of the American Veterinary Medical Association·Edward E PattersonJames R Mickelson
Sep 1, 2005·Journal of Neurology·Emrah DüzelHans-Jochen Heinze
Sep 30, 2005·Epilepsia·Margitta SeeckFrancois Lazeyras
May 17, 2006·NeuroImage·Luiz Eduardo BettingFernando Cendes
Jul 29, 2006·NeuroImage·Leonardo BonilhaLi Min Li
Aug 19, 2007·Brain : a Journal of Neurology·Gwenaëlle DouaudAnthony James
Nov 13, 2007·Epilepsy & Behavior : E&B·Dalin T PulsipherBruce Hermann
Mar 24, 2009·Epilepsy & Behavior : E&B·Gerardo Maria de Araújo FilhoElza Márcia T Yacubian
Apr 3, 2009·Brain : a Journal of Neurology·H BlumenfeldS S Spencer
Jul 3, 2009·Epilepsy Research·Katia LinElza Márcia Targas Yacubian
Aug 7, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jennifer L Whitwell
Dec 17, 2009·Neurobiology of Aging·Luiz K FerreiraMarcus V Zanetti
Apr 15, 2010·Journal of Veterinary Internal Medicine·V HülsmeyerA Fischer
Jun 4, 2010·Expert Review of Neurotherapeutics·Clarissa Lin YasudaFernando Cendes
Oct 27, 2010·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Takayuki KuwabaraHiromitsu Orima
Jan 6, 2011·Neurology·J O'MuircheartaighM P Richardson
Mar 1, 2011·Journal of Neuroradiology. Journal De Neuroradiologie·Wei HuangYijun Liu

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Software Mentioned

MATLAB
- Toolbox
SPM
Dartel
Amira
FSL
FMRIB
SPM12

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