GRIN2B promoter methylation deficits in early-onset schizophrenia and its association with cognitive function

Epigenomics
Helene A FachimGavin P Reynolds

Abstract

We investigated GRIN1 and GRIN2B promoter methylation in first-episode schizophrenia patients compared with siblings and controls, testing for correlations between DNA methylation, cognitive performance and clinical variables. Blood-derived DNA from all groups underwent bisulfite conversion and pyrosequencing to determine methylation at CpG sites within the GRIN1 and GRIN2B promoters and results were compared with the measure of global methylation LINE-1. We found hypomethylation among all CpGs analyzed within GRIN2B promoter in patients and greater LINE-1 methylation in patients and siblings. CpG4 was correlated to a measure of intellectual function. Changes in GRIN2B promoter methylation may represent an environmental influence contributing to glutamatergic dysfunction in psychosis and relate to lower cognitive performance in subjects with first-episode schizophrenia.

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Citations

Nov 27, 2020·Epigenomics·Camila Marcelino LoureiroGavin P Reynolds
Dec 10, 2020·Scientific Reports·Camila Marcelino LoureiroPaulo Louzada-Junior
Mar 18, 2021·Journal of Psychiatric Research·Edyta ReszkaMonika Dmitrzak-Węglarz
Dec 2, 2020·Progress in Neuro-psychopharmacology & Biological Psychiatry·Helene A FachimGavin P Reynolds
Jun 5, 2021·Epigenetics & Chromatin·Xena Giada Pappalardo, Viviana Barra
Jul 29, 2021·Epigenomics·Hamid Mostafavi AbdolmalekySam Thiagalingam
Aug 10, 2021·Frontiers in Neuroscience·Qing ChenPing Lin

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Methods Mentioned

BETA
PCR

Software Mentioned

Statistical Package for Social Sciences ( SPSS
PyroMark Q24

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