Griseofulvin inhibition of polymorphonuclear leucocyte chemotaxis in Boyden chambers.

Scandinavian Journal of Haematology
U BandmannG Simmingsköld

Abstract

Griseofulvin inhibited the chemotaxis of polymorphonuclear leucocytes (PMN's) in vitro in the concentration range 0.1-1.0 mug/ml, i.e. at concentrations comparable to those obtained in serum during peroral treatment with griseofulvin. It is suggested that PMN chemotaxis is inhibited by griseofulvin interference with the redistribution of cytoplasmic microtubules, which is thought to be essential in the direction-finding of PMNs during chemotaxis. Furthermore, it is suggested that the griseofulvin inhibition of PMN chemotaxis - together with the previously known pharmacodynamic properties of griseofulvin - may provide the rationale for griseofulvin therapy in PMN-mediated tissue injury of the gut.

References

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Citations

Dec 1, 1989·Journal of Internal Medicine·B Norberg
Jan 1, 1987·Transactions of the Royal Society of Tropical Medicine and Hygiene·M A Yousif, R J Hay
Mar 1, 1978·International Journal of Dermatology·M V Dahl
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Jan 1, 1984·Scandinavian Journal of Infectious Diseases·O Bäck, B Norberg
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Nov 1, 1988·The Journal of Pharmacy and Pharmacology·N BerradiaC Vigneron
Mar 1, 1988·Mutation Research·L De Carli, L Larizza

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