Groove pancreatitis: a brief review of a diagnostic challenge

Archives of Pathology & Laboratory Medicine
Karyn DeSouza, Laurentia Nodit

Abstract

Groove pancreatitis is an uncommon, yet well-described, type of focal chronic pancreatitis, affecting "the groove"-the area between the head of the pancreas, the duodenum, and the common bile duct. Men aged 40 to 50 years are most commonly affected, with a history of alcohol abuse frequently disclosed. Clinical manifestations are similar to other forms of chronic pancreatitis, and vomiting secondary to duodenal stenosis is the main feature. It is postulated that pancreatitis in the groove area arises from obstruction of pancreatic juices in the ductal system, causing fibrosis and stasis with resultant inflammation of surrounding structures. The minor papilla is frequently the anatomic area of preferential involvement. Groove pancreatitis poses diagnostic challenges, forming a "pseudotumor" that mimics pancreatic carcinoma. The distinction is important, although often impossible to make because of their similar presentation, with groove pancreatitis usually affecting younger patients. Most patients are successfully treated with pancreaticoduodenectomy when definitive pathologic diagnoses can be made.

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Citations

Sep 8, 2017·Nature Reviews. Disease Primers·Jorg KleeffJohn P Neoptolemos
May 7, 2016·BJR Case Reports·Chakenahalli NanjarajTuramari Rashmi
Sep 29, 2019·Abdominal Radiology·Bhavik N PatelAtif Zaheer
Oct 16, 2020·Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva·Paula Martínez de la CruzCristina Verdejo Gil
Nov 13, 2020·Pathologica·Claudio LuchiniGiuseppe Zamboni

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