Ground glass opacities: Imaging, pathology, and gene mutations

The Journal of Thoracic and Cardiovascular Surgery
Fenghao SunQun Wang

Abstract

Lung cancer can be detected in its early stages with computed tomography (CT). Early lung adenocarcinoma often is displayed as ground glass opacity (GGO), an entity that has been well studied over the past decade. However, few studies have focused on the correlation between CT characteristics and pathologic subtype of GGO. We aimed to explore the correlation between CT characteristics, pathologic subtype, and gene mutation associated with GGO in an effort to aid in the treatment of lung adenocarcinoma. In this retrospective study, patients with GGO who underwent surgery in our institution between 2013 and 2016 were included. Patients were divided into 2 groups on the basis of CT characteristics: group 1, diameter <20 mm and solid component <50%; and group 2, diameter ≥20 mm or solid component ≥50%. Differences in pathologic subtype and gene mutation pattern between groups were compared using the χ2 test. The correlation between pathologic subtype and epidermal growth factor receptor (EGFR) mutation was also tested using the χ2 test. A total of 1018 cases (408 in group 1, 610 in group 2) were included; of these, 544 were tested for the EGFR gene mutation. There was a significant difference in predominant subtype (P < .001) and a...Continue Reading

Citations

Mar 21, 2020·Open Medicine·Yuqian ZhangXiang Wang
Dec 27, 2019·The Thoracic and Cardiovascular Surgeon·Zixu LiuYushun Gao
Oct 22, 2020·International Journal of Surgery Case Reports·Motoaki YasukawaChiho Ohbayashi
Dec 15, 2020·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Fenghao SunQun Wang
Oct 30, 2020·Cancer Management and Research·Lishu ZhaoChunhong Hu
Jul 28, 2020·The Journal of Thoracic and Cardiovascular Surgery·Fangqiu FuHaiquan Chen

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