Mar 2, 2018

Group 2 innate lymphocytes at the interface between innate and adaptive immunity

Annals of the New York Academy of Sciences
Martijn J Schuijs, Timotheus Y F Halim

Abstract

Group 2 innate lymphoid cells (ILC2) are innate immune cells that respond rapidly to their environment through soluble inflammatory mediators and cell-to-cell interactions. As tissue-resident sentinels, ILC2 help orchestrate localized type 2 immune responses. These ILC2-driven type 2 responses are now recognized in diverse immune processes, different anatomical locations, and homeostatic or pathological settings. ILC2-derived cytokines and cell surface signaling molecules function as key regulators of innate and adaptive immunity. Conversely, ILC2 are governed by their environment. As such, ILC2 form an important nexus of the immune system and may present an attractive target for immune modulation in disease.

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References

Mentioned in this Paper

TSLP protein, human
Interleukins
Immune Response
Immune System
Lymphocyte Subset
Immune Effector Cell
Lymphocytes as Percentage of Blood Leukocytes (Lab Test)
Inflammation Mediators
Tissue Specificity
Environment

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