Group 2 innate lymphoid cells in lung inflammation

Immunology
B W S Li, Rudi W Hendriks

Abstract

Although allergic asthma is a heterogeneous disease, allergen-specific T helper 2 (Th2) cells producing the key cytokines involved in type 2 inflammation, interleukin-4 (IL-4), IL-5 and IL-13, are thought to play a major role in asthma pathogenesis. This model is challenged by the recent discovery of group 2 innate lymphoid cells (ILC2) that represent a critical innate source of type 2 cytokines. These ILC2 are activated by epithelial cell-derived cytokines, including IL-25 and IL-33, which have been implicated in the initiation of asthma. In this review, we will discuss recent studies supporting a significant role for ILC2 in lung inflammation, with special attention to allergen-induced asthma.

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Related Concepts

Pathogenic Aspects
C19orf10 gene
Pathogenesis
Recombinant Interleukin-5
Lymphoid Cells
Transcription Initiation
Allergens
Allergen (brand of diphenylpyraline)
Interleukin-25 Binding Activity
Asthma

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